Universität zu Köln

Martin, Anna, Lang, Sonja, Goeser, Tobias, Demir, Muenevver, Steffen, Hans-Michael and Kasper, Philipp ORCID: 0000-0002-6218-2239 (2022). Management of Dyslipidemia in Patients with Non-Alcoholic Fatty Liver Disease. Curr. Atheroscleros. Rep., 24 (7). S. 533 - 547. PHILADELPHIA: CURRENT MEDICINE GROUP. ISSN 1534-6242

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Abstract

Purpose of Review Patients with non-alcoholic fatty liver disease (NAFLD), often considered as the hepatic manifestation of the metabolic syndrome, represent a population at high cardiovascular risk and frequently suffer from atherogenic dyslipidemia. This article reviews the pathogenic interrelationship between NAFLD and dyslipidemia, elucidates underlying pathophysiological mechanisms and focuses on management approaches for dyslipidemic patients with NAFLD. Recent Findings Atherogenic dyslipidemia in patients with NAFLD results from hepatic and peripheral insulin resistance along with associated alterations of hepatic glucose and lipoprotein metabolism, gut dysbiosis, and genetic factors. Since atherogenic dyslipidemia and NAFLD share a bi-directional relationship and are both major driving forces of atherosclerotic cardiovascular disease (ASCVD) development, early detection and adequate treatment are warranted. Thus, integrative screening and management programs are urgently needed. A stepwise approach for dyslipidemic patients with NAFLD includes (i) characterization of dyslipidemia phenotype, (ii) individual risk stratification, (iii) definition of treatment targets, (iv) lifestyle modification, and (v) pharmacotherapy if indicated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Martin, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeser, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Demir, Muenevver UNSPECIFIED UNSPECIFIED UNSPECIFIED Steffen, Hans-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasper, Philipp UNSPECIFIED orcid.org/0000-0002-6218-2239 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671412
DOI:	10.1007/s11883-022-01028-4
Journal or Publication Title:	Curr. Atheroscleros. Rep.
Volume:	24
Number:	7
Page Range:	S. 533 - 547
Date:	2022
Publisher:	CURRENT MEDICINE GROUP
Place of Publication:	PHILADELPHIA
ISSN:	1534-6242
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE; WEIGHT-LOSS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; CONTROLLED-TRIAL; 10-YEAR RISK; ASSOCIATION; STEATOHEPATITIS; METAANALYSIS Multiple languages Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67141