Stich, Maximilian ORCID: 0000-0002-6237-9058, Di Cristanziano, Veronica, Toenshoff, Burkhard ORCID: 0000-0002-6598-6910, Weber, Lutz Thorsten, Doetsch, Jorg, Rammer, Marian Theodor ORCID: 0000-0002-3587-5929, Rieger, Susanne, Heger, Eva, Garbade, Sven F., Burgmaier, Kathrin, Benning, Louise, Speer, Claudius, Habbig, Sandra and Haumann, Sophie . Humoral immune response and live-virus neutralization of the SARS-CoV-2 omicron (BA.1) variant after COVID-19 mRNA vaccination in children and young adults with chronic kidney disease. Pediatr. Nephrol.. NEW YORK: SPRINGER. ISSN 1432-198X

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Abstract

Background Data on humoral immune response to standard COVID-19 vaccination are scarce in adolescent patients and lacking for children below 12 years of age with chronic kidney disease including kidney transplant recipients. Methods We therefore investigated in this retrospective two-center study (DRKS00024668; registered 23.03.2021) the humoral immune response to a standard two-dose mRNA vaccine regimen in 123 CKD patients aged 5-30 years. A live-virus assay was used to assess the serum neutralizing activity against the SARS-CoV-2 omicron (BA.1) variant. Results Children aged 5-11 years had a comparable rate and degree of immune response to adolescents despite lower vaccine doses (10 mu g vs. 30 mu g BNT162b2). Treatment with two (odds ratio 9.24) or three or more (odds ratio 17.07) immunosuppressants was an independent risk factor for nonresponse. The immune response differed significantly among three patient cohorts: 48 of 77 (62.3%) kidney transplant recipients, 21 of 26 (80.8%) patients on immunosuppressive therapy, and 19 of 20 (95.0%) patients with chronic kidney disease without immunosuppressive therapy responded. In the kidney transplant recipients, immunosuppressive regimens comprising mycophenolate mofetil, an eGFR of< 60 mL/min/1.73 m(2), and female sex were independent risk factors for nonresponse. Two of 18 (11.1%) and 8 of 16 (50.0%) patients with an anti-S1-RBD IgG of 100-1411 and > 1411 BAU/mL, respectively, showed a neutralization activity against the omicron variant. Conclusion A standard mRNA vaccine regimen in immunosuppressed children and adolescents with kidney disease elicits an attenuated humoral immune response with effective live virus neutralization against the omicron variant in approximately 10% of the patients, underlying the need for omicron-adapted vaccination.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stich, MaximilianUNSPECIFIEDorcid.org/0000-0002-6237-9058UNSPECIFIED
Di Cristanziano, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toenshoff, BurkhardUNSPECIFIEDorcid.org/0000-0002-6598-6910UNSPECIFIED
Weber, Lutz ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doetsch, JorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rammer, Marian TheodorUNSPECIFIEDorcid.org/0000-0002-3587-5929UNSPECIFIED
Rieger, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heger, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garbade, Sven F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgmaier, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benning, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Speer, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Habbig, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haumann, SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-672206
DOI: 10.1007/s00467-022-05806-9
Journal or Publication Title: Pediatr. Nephrol.
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-198X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRANSPLANT RECIPIENTSMultiple languages
Pediatrics; Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/67220

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