Petry-Schmelzer, Jan Niklas, Schwarz, Lisa M., Jergas, Hannah, Reker, Paul, Steffen, Julia K., Dafsari, Haidar S., Baldermann, Juan Carlos, Fink, Gereon R. 
ORCID: 0000-0002-8230-1856, Visser-Vandewalle, Veerle, Dembek, Till A. and Barbe, Michael T.
(2022).
A Randomized, Double-Blinded Crossover Trial of Short Versus Conventional Pulse Width Subthalamic Deep Brain Stimulation in Parkinson's Disease.
J. Parkinsons Dis., 12 (5).
S. 1497 - 1506.
AMSTERDAM:
IOS PRESS.
ISSN 1877-718X
Abstract
Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for patients with Parkinson's disease. Previous acute challenge studies suggested that short pulse widths might increase the therapeutic window while maintaining motor symptom control with a decrease in energy consumption. However, only little is known about the effect of short pulse width stimulation beyond the setting of an acute challenge. Objective: To compare 4 weeks of STN-DBS with conventional pulse width stimulation (60 mu s) to 4 weeks of STN-DBS with short pulse width stimulation (30 mu s) regarding motor symptom control. Methods: This study was a monocentric, double-blinded, randomized crossover non-inferiority trial investigating whether short pulse width stimulation with 30 mu s maintains equal motor control as conventional 60 mu s stimulation over a period of 4 weeks (German Clinical Trials Register No. DRKS00017528). Primary outcome was the difference in motor symptom control as assessed by a motor diary. Secondary outcomes included energy consumption measures, non-motor effects, side-effects, and quality of life. Results: Due to a high dropout rate, the calculated sample size of 27 patients was not met and 24 patients with Parkinson's disease and STN-DBS were included in the final analysis. However, there were no differences in any investigated outcome parameter between the two treatment conditions. Conclusion: This study demonstrates that short pulse width settings (30 mu s) provide non-inferior motor symptom control as conventional (60 mu s) stimulation without significant differences in energy consumption. Future studies are warranted to evaluate a potential benefit of short pulse width settings in patients with pronounced dyskinesia.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||
| Creators: |
|
||||||||||||||||||||||||||||||||||||||||||||||||
| URN: | urn:nbn:de:hbz:38-672330 | ||||||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.3233/JPD-213119 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | J. Parkinsons Dis. | ||||||||||||||||||||||||||||||||||||||||||||||||
| Volume: | 12 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Number: | 5 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Page Range: | S. 1497 - 1506 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Date: | 2022 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | IOS PRESS | ||||||||||||||||||||||||||||||||||||||||||||||||
| Place of Publication: | AMSTERDAM | ||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1877-718X | ||||||||||||||||||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||
| Uncontrolled Keywords: |
|
||||||||||||||||||||||||||||||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/67233 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
 |
View Item |