Koehler, Felix C., Fu, Chun-Yu, Spaeth, Martin R., Hoyer-Allo, K. Johanna R., Bohl, Katrin ORCID: 0000-0003-3746-4047, Goebel, Heike ORCID: 0000-0002-0171-7025, Lackmann, Jan-Wilm, Grundmann, Franziska, Osterholt, Thomas ORCID: 0000-0001-5047-0252, Gloistein, Claas, Steiner, Joachim D., Antebi, Adam, Benzing, Thomas ORCID: 0000-0003-0512-1066, Schermer, Bernhard ORCID: 0000-0002-5194-9000, Schwarz, Guenter, Burst, Volker and Mueller, Roman-Ulrich (2022). A systematic analysis of diet-induced nephroprotection reveals overlapping changes in cysteine catabolism. Transl. Res., 244. S. 32 - 47. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-1810

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Abstract

Caloric Restriction (CR) extends lifespan and augments cellular stress-resistance from yeast to primates, making CR an attractive strategy for organ protection in the clinic. Translation of CR to patients is complex, due to problems regarding adherence, feasibility, and safety concerns in frail patients. Novel tailored dietary regimens, which modulate the dietary composition of macro-and micronutrients rather than reducing calorie intake promise similar protective effects and increased translatability. However, a direct head-to-head comparison to identify the most potent approach for organ protection, as well as overlapping metabolic consequences have not been performed. We systematically analyzed six dietary preconditioning protocols -fasting mimicking diet (FMD), ketogenic diet (KD), dietary restriction of branched chained amino acids (BCAA), two dietary regimens restricting sulfur -containing amino acids (SR80/100) and CR -in a rodent model of renal ischemia-reperfusion injury (IRI) to quantify diet-induced resilience in kidneys. Of the administered diets, FMD, SR80/100 and CR efficiently protect from kidney damage after IRI. Interestingly, these approaches show overlapping changes in oxidative and hydrogen sulfide (H2S)-dependent cysteine catabolism as a potential common mechanism of organ protection.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Koehler, Felix C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fu, Chun-YuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spaeth, Martin R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoyer-Allo, K. Johanna R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bohl, KatrinUNSPECIFIEDorcid.org/0000-0003-3746-4047UNSPECIFIED
Goebel, HeikeUNSPECIFIEDorcid.org/0000-0002-0171-7025UNSPECIFIED
Lackmann, Jan-WilmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grundmann, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osterholt, ThomasUNSPECIFIEDorcid.org/0000-0001-5047-0252UNSPECIFIED
Gloistein, ClaasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steiner, Joachim D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antebi, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benzing, ThomasUNSPECIFIEDorcid.org/0000-0003-0512-1066UNSPECIFIED
Schermer, BernhardUNSPECIFIEDorcid.org/0000-0002-5194-9000UNSPECIFIED
Schwarz, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burst, VolkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Roman-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-672379
DOI: 10.1016/j.trsl.2022.02.003
Journal or Publication Title: Transl. Res.
Volume: 244
Page Range: S. 32 - 47
Date: 2022
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1878-1810
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CALORIC RESTRICTION; MOLYBDENUM COFACTOR; LIFE-SPAN; OXIDATIVE STRESS; HEALTH; MECHANISMS; APOPTOSIS; INJURY; REGENERATION; SIGNATURESMultiple languages
Medical Laboratory Technology; Medicine, General & Internal; Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/67237

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