Universität zu Köln

Wolf, Alexander ORCID: 0000-0001-8875-586X, Fink, Tobias, Hinkelbein, Jochen, Mertke, Thilo, Volk, Thomas and Mathes, Alexander (2022). Resveratrol therapy improves liver function via estrogen-receptors after hemorrhagic shock in rats. PLoS One, 17 (10). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background Resveratrol may improve organ dysfunction after experimental hemorrhagic or septic shock, and some of these effects appear to be mediated by estrogen receptors. However, the influence of resveratrol on liver function and hepatic microcirculation after hemorrhagic shock is unknown, and a presumed mediation via estrogen receptors has not been investigated in this context. Methods Male Sprague-Dawley rats (200-300g, n = 14/group) underwent hemorrhagic shock for 90 min (MAP 355 mmHg) and were resuscitated with shed blood and Ringer's solution. Animals were treated intravenously with vehicle (1% EtOH), resveratrol (0.2 mg/kg), the unselective estrogen receptor antagonist ICI 182,780 (0.05 mg/kg) or resveratrol + ICI 182,780 prior to retransfusion. Sham-operated animals did not undergo hemorrhage but were treated likewise. After 2 hours of reperfusion, liver function was assessed either by plasma disappearance rate of indocyanine green (PDRICG) or evaluation of hepatic perfusion and hepatic integrity by intravital microscopy, serum enzyme as well as cytokine levels. Results Compared to vehicle controls, administration of resveratrol significantly improved PDRICG, hepatic perfusion index and hepatic integrity after hemorrhagic shock. The co-administration of ICI 182,780 completely abolished the protective effect only with regard to liver function. Conclusions This study shows that resveratrol may improve liver function and hepatocellular integrity after hemorrhagic shock in rats; estrogen receptors mediate these effects at least partially.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wolf, Alexander UNSPECIFIED orcid.org/0000-0001-8875-586X UNSPECIFIED Fink, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinkelbein, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Mertke, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Volk, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathes, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-672500
DOI:	10.1371/journal.pone.0275632
Journal or Publication Title:	PLoS One
Volume:	17
Number:	10
Date:	2022
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPATIC PERFUSION; OXIDATIVE STRESS; HEAT-STRESS; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; MELATONIN RECEPTORS; TRAUMA-HEMORRHAGE; SIRTUIN 1; INJURY; SEPSIS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67250