Universität zu Köln

Gaca, Piotr Jakub, Lewandowicz, Michael, Lipczynska-Lewandowska, Malgorzata, Simon, Michael, Matos, Philomena A. Wawer, Doulis, Alexandros, Rokohl, Alexander C. and Heindl, Ludwig M. (2022). Embryonic Development of the Orbit. Klinische Monatsblat. Augenheilkunde, 239 (1). S. 19 - 27. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

The embryonic and fetal development of the orbit comprises a series of sequential events, starting with the fertilization of the ovum and extending until birth. Most of the publications dealing with orbital morphogenesis describe the sequential development of each germinal layer, the ectoderm with its neuroectoderm derivative and the mesoderm. This approach provides a clear understanding of the mode of development of each layer but does not give the reader a general picture of the structure of the orbit within any specified time frame. In order to enhance our understanding of the developmental anatomy of the orbit, the authors have summarized the recent developments in orbital morphogenesis, a temporally precise and morphogenetically intricate process. Understanding this multidimensional process of development in prenatal life, identifying and linking signaling cascades, as well as the regulatory genes linked to existing diseases, may pave the way for advanced molecular diagnostic testing, developing minimally invasive interventions, and the use of progenitor/ stem cell and even regenerative therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gaca, Piotr Jakub UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewandowicz, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Lipczynska-Lewandowska, Malgorzata UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Matos, Philomena A. Wawer UNSPECIFIED UNSPECIFIED UNSPECIFIED Doulis, Alexandros UNSPECIFIED UNSPECIFIED UNSPECIFIED Rokohl, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-673065
DOI:	10.1055/a-1709-1310
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	239
Number:	1
Page Range:	S. 19 - 27
Date:	2022
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CRANIAL NERVE DEVELOPMENT; NEURAL CREST; HUMAN FETUSES; EMBRYOLOGY; EYE; MORPHOGENESIS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67306