Universität zu Köln

Pieper, K., Dechene, A., Kathemann, S., Pilic, D., Huenseler, C., Weber, L. T., Bergheim, C., Paul, A., Baba, H. A., Hoyer, P. F. and Lainka, E. (2022). Persistent transaminase elevation and hepatopathy after severe underlying disease in early childhood Secondary sclerosing cholangitis of critically ill patients. Mon.schr. Kinderheilkd., 170 (2). S. 146 - 153. NEW YORK: SPRINGER. ISSN 1433-0474

Full text not available from this repository.

Abstract

Secondary sclerosing cholangitis in critically ill patients (SSC-CIP) is a rare disease in adult patients undergoing intensive medical treatment and is almost undescribed in childhood. In patients without pre-existing liver disease, a severe underlying disease with critical hypoperfusion of the vascular plexus and subsequent ischemic injury of the intrahepatic bile ducts (e.g. due to shock or sepsis) leads to rapidly progressive biliary destruction with only few causal therapeutic options. The diagnostic gold standard is endoscopic retrograde cholangiography (ERC) with the possibility of an intervention, especially since noninvasive diagnostics, e.g. sonography, magnetic resonance cholangiography (MRC) have a poor sensitivity in very young patients. In high-grade peripheral bile duct loss and biliary liver cirrhosis, liver transplantation is the only curative treatment approach. The SSC-CIP is an entity that is likely to be diagnosed more frequently in the future and is a relevant complication in critically ill children after survival of the underlying disease. This article describes the clinical courses in three children with SSC-IP who rapidly developed biliary cirrhosis and were successfully treated with a liver transplantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pieper, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dechene, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kathemann, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilic, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huenseler, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, L. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergheim, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paul, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baba, H. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyer, P. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lainka, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-673496
DOI:	10.1007/s00112-019-00788-9
Journal or Publication Title:	Mon.schr. Kinderheilkd.
Volume:	170
Number:	2
Page Range:	S. 146 - 153
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0474
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67349