Universität zu Köln

Maia, Ana, Schoellhorn, Anna, Schuhmacher, Juliane ORCID: 0000-0003-0553-3474 and Gouttefangeas, Cecile . CAF-immune cell crosstalk and its impact in immunotherapy. Semin. Immunopathol.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2300

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Abstract

Tumour cells do not exist as isolated entities. Instead, they are surrounded by a variety of cells and extracellular matrix, which form the tumour microenvironment (TME). The interaction between cancer cells and their microenvironment is increasingly acknowledged as essential in dictating the outcome of the patients. The TME includes everything that surrounds tumour cells and is often highjacked by the latter to promote their growth, invasion, and immune escape. Immune cells and cancer-associated fibroblasts (CAFs) are essential components of the TME, and there is increasing evidence that their interaction constitutes a major player not only for tumour progression but also for therapy response.Recent work in the field of immuno-oncology resulted in the development of novel therapies that aim at activating immune cells against cancer cells to eliminate them. Despite their unprecedented success, the lack of response from a large portion of patients highlights the need for further progress and improvement. To achieve its ultimate goal, the interaction between cancer cells and the TME needs to be studied in-depth to allow the targeting of mechanisms that are involved in resistance or refractoriness to therapy. Moreover, predictive and prognostic biomarkers for patient stratification are still missing. In this review, we focus on and highlight the complexity of CAFs within the TME and how their interaction, particularly with immune cells, can contribute to treatment failure. We further discuss how this crosstalk can be further dissected and which strategies are currently used to target them.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Maia, Ana UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoellhorn, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuhmacher, Juliane UNSPECIFIED orcid.org/0000-0003-0553-3474 UNSPECIFIED Gouttefangeas, Cecile UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-673518
DOI:	10.1007/s00281-022-00977-x
Journal or Publication Title:	Semin. Immunopathol.
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-2300
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARCINOMA-ASSOCIATED FIBROBLASTS; TUMOR-ASSOCIATED FIBROBLASTS; TGF-BETA; T-CELLS; CANCER; RECEPTOR; EXPRESSION; BLOCKADE; DEFINES; HETEROGENEITY Multiple languages Immunology; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67351