Universität zu Köln

Fassbender, Ronja V., Goedecke, Jana, Visser-Vandewalle, Veerle, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Onur, Oezguer A. (2022). Brain Stimulation for the Treatment of Dementia. Forschritte Neurol. Psychiatr., 90 (07/08). S. 336 - 343. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3522

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Abstract

Due to the increasing number of cases of Alzheimer's disease and the relatively moderate success with the available symptomatic and causal pharmacological therapies, there is a considerable need to explore non-pharmacological treatment options. In the field of non-invasive brain stimulation (NIBS), various methods have been investigated, particularly transcranial magnetic stimulation and transcranial electrical stimulation. In addition, deep brain stimulation (DBS) is currently being researched as an innovative method for targeted neuromodulation. Both non-invasive and invasive approaches aim to modulate neuronal activity and improve cognitive-mnestic functions. Secondary mechanisms such as long-term potentiation in NIBS or neurogenesis in DBS could also achieve long-term positive effects. Preclinical and clinical studies have already shown promising results in patients in early stages of Alzheimer's disease. However, inconsistent study and stimulation protocols and small sample sizes make it difficult to assess efficacy. Further research is warranted to enable the use of non-invasive or invasive neuromodulatory approaches in clinical practice in the near future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fassbender, Ronja V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goedecke, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674011
DOI:	10.1055/a-1787-0335
Journal or Publication Title:	Forschritte Neurol. Psychiatr.
Volume:	90
Number:	07/08
Page Range:	S. 336 - 343
Date:	2022
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3522
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; ALZHEIMERS-DISEASE; NUCLEUS BASALIS; DOUBLE-BLIND; FORNIX; MEYNERT; MEMORY Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67401