Universität zu Köln

Niels, Timo, Baltin, Christoph T., Kosanke, Guido, Fetzner, Ulrich K., Hoelscher, Arnulf H., Bollschweiler, Elfriede, Naendrup, Jan-Hendrik and Baumann, Freerk T. (2022). Does VO(2)peak Provide a Prognostic Value in Esophagectomy and Gastrectomy for Post-operative Outcomes? In Vivo, 36 (4). S. 1812 - 1820. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7549

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Abstract

Background/Aim: Esophagectomy and gastrectomy are procedures with considerable physical burden and intense post-operative care of which the patient's physical condition seems to be a relevant predictor. The gold standard of the cardiorespiratory fitness is the peak oxygen consumption (VO(2)peak). This pilot study examined the prognostic value of VO(2)peak on post-surgery outcomes in esophageal and gastric cancer patients. Patients and Methods: In this prospective cross-sectional study, patients scheduled for esophagectomy or gastrectomy were examined 24 h before the surgery regarding their VO(2)peak. The post-operative complications according to Clavien-Dindo grade IIIb/IV/V, Intensive-Care-Unit days, and overall hospital stay were documented following surgery. In a subset, body weight changes from surgery until hospital discharge and first aftercare visit were recorded. Results: The functional capacity was significantly reduced in 34/35 of the included patients compared to matched norm-values (p<0.01). The only significant correlation was found between VO(2)peak values and body weight change from surgery to the first aftercare visit. A subgroup comparison of patients with a VO(2)peak <17 ml/min/kg and >= 17 ml/min/kg suggested small, non-significant differences in post-surgery outcomes and significant differences in the body weight change from surgery to hospital discharge, favoring the higher-VO(2)peak subgroup. Conclusion: The impaired functional capacity following esophagectomy or gastrectomy may strengthen the rational for exercise programs during neoadjuvant and pre-surgery phases. The prognostic value of VO(2)peak on post-operative outcomes remains uncertain due to noticeable descriptive differences, but no significant correlations, potentially limited by the small-sized population. Nonetheless, a correlation between VO(2)peak and body weight change post-surgery was observed and indicates a potential prognostic value of VO(2)peak.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Niels, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Baltin, Christoph T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kosanke, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Fetzner, Ulrich K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, Arnulf H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bollschweiler, Elfriede UNSPECIFIED UNSPECIFIED UNSPECIFIED Naendrup, Jan-Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Freerk T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674149
DOI:	10.21873/invivo.12897
Journal or Publication Title:	In Vivo
Volume:	36
Number:	4
Page Range:	S. 1812 - 1820
Date:	2022
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7549
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HAND GRIP STRENGTH; NEOADJUVANT CHEMOTHERAPY; PHYSICAL-FITNESS; COMPLICATIONS; CANCER; PROGRAM; IMPACT Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67414