Voeckel, Jasper, Sigrist, Christine ORCID: 0000-0002-6718-3230, Kaess, Michael ORCID: 0000-0003-0031-7764 and Koenig, Julian (2023). Predictors of treatment non-response for depression in a sample of female adolescents with risk-taking and self-injurious behavior - A one year follow-up. J. Affect. Disord., 324. S. 129 - 136. AMSTERDAM: ELSEVIER. ISSN 1573-2517

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Objective: Depressive disorders (DD) are highly prevalent among adolescents. While up to 60 % do not respond to treatment, evidence on predictors of treatment non-response in this age group is mixed, impeding meaningful clinical implications. Drawing on a consecutive clinical cohort of adolescents with risk taking and self-injurious behavior, the present study aimed to identify predictors of treatment non-response for female DD in a naturalistic one year follow-up. Methods: The sample comprised female adolescents with verified DD (n = 152). Patients underwent assessments at baseline (T0) and follow-up (T1). Sociodemographic factors (e.g., age), clinical measures (e.g., symptom severity, trauma), and treatment variables (e.g. number of psychotherapy sessions), were analyzed as potential predictors of treatment non-response in unadjusted analyses and analyses adjusting for treatment intensity and age at baseline. Treatment response was defined based on not fulfilling formal diagnosis for DD at follow-up (52.3 %; n = 80) or the 50 % decrease in self-reported depressive symptoms (21.1 %; n = 32) from T0 to T1. Results: Greater depressive and overall symptom severity, greater frequency of self-injuries, history of suicide attempts and history of childhood trauma at T0 were robustly associated with treatment non-response based on diagnostic interviews. Only a lower number of siblings was robustly associated with treatment non-response based on self-reports. Limitations: Findings may not generalize to other treatment settings. Conclusion: Collectively, our results highlight overall symptom severity as significant predictor of treatment non -response in female adolescents with depression. Methodological differences (interviews versus self-reports) and potential implications from these findings for clinical practice are discussed.

Item Type: Journal Article
CreatorsEmailORCIDORCID Put Code
Sigrist, ChristineUNSPECIFIEDorcid.org/0000-0002-6718-3230UNSPECIFIED
Kaess, MichaelUNSPECIFIEDorcid.org/0000-0003-0031-7764UNSPECIFIED
URN: urn:nbn:de:hbz:38-674663
DOI: 10.1016/j.jad.2022.12.073
Journal or Publication Title: J. Affect. Disord.
Volume: 324
Page Range: S. 129 - 136
Date: 2023
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1573-2517
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
Clinical Neurology; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/67466


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