Universität zu Köln

Wani, Gulzar A., Sprenger, Hans-Georg, Ndoci, Kristiano, Chandragiri, Srikanth, Acton, Richard James ORCID: 0000-0002-2574-9611, Schatton, Desiree, Kochan, Sandra M. V., Sakthivelu, Vignesh, Jevtic, Milica, Seeger, Jens M., Mueller, Stefan, Giavalisco, Patrick, Rugarli, Elena I., Motori, Elisa ORCID: 0000-0001-5997-6866, Langer, Thomas and Bergami, Matteo (2022). Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. Cell Reports, 38 (7). CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

The transition between quiescence and activation in neural stem and progenitor cells (NSPCs) is coupled with reversible changes in energy metabolism with key implications for lifelong NSPC self-renewal and neurogenesis. How this metabolic plasticity is ensured between NSPC activity states is unclear. We find that a state specific rewiring of the mitochondrial proteome by the i-AAA peptidase YME1L is required to preserve NSPC self-renewal. YME1L controls the abundance of numerous mitochondrial substrates in quiescent NSPCs, and its deletion activates a differentiation program characterized by broad metabolic changes causing the irreversible shift away from a fatty-acid-oxidation-dependent state. Conditional Yme1l deletion in adult NSPCs in vivo results in defective self-renewal and premature differentiation, ultimately leading to NSPC pool depletion. Our results disclose an important role for YME1L in coordinating the switch between metabolic states of NSPCs and suggest that NSPC fate is regulated by compartmentalized changes in protein network dynamics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wani, Gulzar A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sprenger, Hans-Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Ndoci, Kristiano UNSPECIFIED UNSPECIFIED UNSPECIFIED Chandragiri, Srikanth UNSPECIFIED UNSPECIFIED UNSPECIFIED Acton, Richard James UNSPECIFIED orcid.org/0000-0002-2574-9611 UNSPECIFIED Schatton, Desiree UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochan, Sandra M. V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sakthivelu, Vignesh UNSPECIFIED UNSPECIFIED UNSPECIFIED Jevtic, Milica UNSPECIFIED UNSPECIFIED UNSPECIFIED Seeger, Jens M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Giavalisco, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Rugarli, Elena I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Motori, Elisa UNSPECIFIED orcid.org/0000-0001-5997-6866 UNSPECIFIED Langer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergami, Matteo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674842
DOI:	10.1016/j.celrep.2022.110370
Journal or Publication Title:	Cell Reports
Volume:	38
Number:	7
Date:	2022
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	2211-1247
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MASS-SPECTROMETRY; SUBVENTRICULAR ZONE; REVEALS; OPA1; DYNAMICS; FUSION; NEUROGENESIS; QUIESCENCE; PHENOTYPES; ENERGY Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67484