Universität zu Köln

Fattahi, Mojdeh, Eskandari, Kiarash, Sayehmiri, Fatemeh, Kuhn, Jens ORCID: 0000-0002-4719-5293 and Haghparast, Abbas (2022). Deep brain stimulation for opioid use disorder: A systematic review of preclinical and clinical evidence. Brain Res. Bull., 187. S. 39 - 49. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-2747

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Abstract

Opioid use disorder (OUD) is a chronic and complex disease characterized by repeated relapses and remissions. Deep brain stimulation (DBS) has been discussed again and again as a potentially helpful neuromodulatory procedure in this context. In this review, for the first time, we intended to systematically identify the positive and negative effects of DBS in human and animal models of opioid dependence to assess the viability of DBS as a treatment of OUD. Eligible studies were incorporated by a comprehensive literature search and evaluated through proper methodological quality assessment tools. Findings showed that the nucleus accumbens was the most stimulated brain target in human and animal studies, and DBS was applied chiefly in the form of highfrequency stimulation (HFS). DBS administration effectively reduced opioid craving and consumption in human and animal subjects dependent on opioids. DBS represents a valuable alternative strategy for treating intractable opioid addiction. Based on our systematic literature analysis, research efforts in this field should be continued.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fattahi, Mojdeh UNSPECIFIED UNSPECIFIED UNSPECIFIED Eskandari, Kiarash UNSPECIFIED UNSPECIFIED UNSPECIFIED Sayehmiri, Fatemeh UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED orcid.org/0000-0002-4719-5293 UNSPECIFIED Haghparast, Abbas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675351
DOI:	10.1016/j.brainresbull.2022.06.015
Journal or Publication Title:	Brain Res. Bull.
Volume:	187
Page Range:	S. 39 - 49
Date:	2022
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-2747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEUS-ACCUMBENS SHELL; CONTEXT-INDUCED REINSTATEMENT; HEROIN-SEEKING BEHAVIORS; ELECTRICAL-STIMULATION; COCAINE SEEKING; DRUG; ALCOHOL; EXTINCTION; MODULATION; EFFICACY Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67535