Universität zu Köln

Polidori, Maria Cristina and Mecocci, Patrizia ORCID: 0000-0003-0729-5246 (2022). Modeling the dynamics of energy imbalance: The free radical theory of aging and frailty revisited. Free Radic. Biol. Med., 181. S. 235 - 241. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-4596

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Abstract

The role of oxidative stress in aging and the newly conceptualized vision of frailty is of great interest for the possibility to define a framework able to explain the several modifications observed in all biological molecules along with age. In this review, the impact of oxidative stress is considered in aging processes as well as in frailty, the geriatric concept of declined capacity to cope with any stressor, leading to a status of reduced ability to maintain the homeostatic balance. Although some pharmacological and behavioral approaches have been proposed, we are still lacking efficacious management able to prevent and avoid frailty. This represents a fundamental challenge for future research in this field.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Polidori, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Mecocci, Patrizia UNSPECIFIED orcid.org/0000-0003-0729-5246 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675680
DOI:	10.1016/j.freeradbiomed.2022.02.009
Journal or Publication Title:	Free Radic. Biol. Med.
Volume:	181
Page Range:	S. 235 - 241
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-4596
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AGE-DEPENDENT INCREASES; VITAMIN-E FORMS; OXIDATIVE STRESS; MITOCHONDRIAL-DNA; PLASMA-LEVELS; DAMAGE; HEALTH; RISK Multiple languages Biochemistry & Molecular Biology; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67568