Universität zu Köln

Banwinkler, Magdalena ORCID: 0000-0001-7086-9973, Theis, Hendrik, Prange, Stephane ORCID: 0000-0002-0812-7634 and van Eimeren, Thilo (2022). Imaging the Limbic System in Parkinson's Disease-A Review of Limbic Pathology and Clinical Symptoms. Brain Sci., 12 (9). BASEL: MDPI. ISSN 2076-3425

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Abstract

The limbic system describes a complex of brain structures central for memory, learning, as well as goal directed and emotional behavior. In addition to pathological studies, recent findings using in vivo structural and functional imaging of the brain pinpoint the vulnerability of limbic structures to neurodegeneration in Parkinson's disease (PD) throughout the disease course. Accordingly, dysfunction of the limbic system is critically related to the symptom complex which characterizes PD, including neuropsychiatric, vegetative, and motor symptoms, and their heterogeneity in patients with PD. The aim of this systematic review was to put the spotlight on neuroimaging of the limbic system in PD and to give an overview of the most important structures affected by the disease, their function, disease related alterations, and corresponding clinical manifestations. PubMed was searched in order to identify the most recent studies that investigate the limbic system in PD with the help of neuroimaging methods. First, PD related neuropathological changes and corresponding clinical symptoms of each limbic system region are reviewed, and, finally, a network integration of the limbic system within the complex of PD pathology is discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Banwinkler, Magdalena UNSPECIFIED orcid.org/0000-0001-7086-9973 UNSPECIFIED Theis, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Prange, Stephane UNSPECIFIED orcid.org/0000-0002-0812-7634 UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675959
DOI:	10.3390/brainsci12091248
Journal or Publication Title:	Brain Sci.
Volume:	12
Number:	9
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEEP BRAIN-STIMULATION; BASAL FOREBRAIN DEGENERATION; MILD COGNITIVE IMPAIRMENT; IMPULSE CONTROL DISORDERS; WHITE-MATTER; FUNCTIONAL CONNECTIVITY; HIPPOCAMPAL SUBFIELDS; VENTRAL STRIATUM; STRUCTURAL CONNECTIVITY; DEPRESSIVE SYMPTOMS Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67595