Universität zu Köln

Lorenz, Florian ORCID: 0000-0002-8535-5243, Brunner, Stefanie, Berlth, Felix, Dratsch, Thomas, Babic, Benjamin, Fuchs, Hans Friedrich, Schmidt, Thomas, Celik, Erkan ORCID: 0000-0001-5687-7707, dos Santos, Daniel Pinto, Grimminger, Peter, Bruns, Christiane Josephine, Goeser, Tobias and Chon, Seung-Hun ORCID: 0000-0002-8923-6428 (2023). Using an Endoluminal Functional Lumen Imaging Probe (EndoFLIP (TM)) to Compare Pyloric Function in Patients with Gastroparesis to Patients After Esophagectomy. J. Gastrointest. Surg., 27 (4). S. 682 - 691. NEW YORK: SPRINGER. ISSN 1873-4626

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Abstract

Background Gastroparesis (GP) occurs in patients after upper gastrointestinal surgery, in patients with diabetes or systemic sclerosis and in idiopathic GP patients. As pyloric dysfunction is considered one of the underlying mechanisms, measuring this mechanism with EndoFLIP (TM) can lead to a better understanding of the disease. Methods Between November 2021 and March 2022, we performed a retrospective single-centre study of all patients who had non-surgical GP, post-surgical GP and no sign of GP after esophagectomy and who underwent our post-surgery follow-up program with surveillance endoscopies and further exams. EndoFLIP (TM) was used to perform measurements of the pylorus, and distensibility was measured at 40 ml, 45 ml and 50 ml balloon filling. Results We included 66 patients, and successful application of the EndoFLIP (TM) was achieved in all interventions (n = 66, 100%). We identified 18 patients suffering from non-surgical GP, 23 patients suffering from GP after surgery and 25 patients without GP after esophagectomy. At 40, 45 and 50 ml balloon filling, the mean distensibility in gastroparetic patients was 8.2, 6.2 and 4.5 mm(2)/mmHg; 5.4, 5.1 and 4.7 mm(2)/mmHg in post-surgical patients suffering of GP; and 8.5, 7.6 and 6.3 mm(2)/mmHg in asymptomatic post-surgical patients. Differences between symptomatic and asymptomatic patients were significant. Conclusion Measurement with EndoFLIP (TM) showed that asymptomatic post-surgery patients seem to have a higher pyloric distensibility. Pyloric distensibility and symptoms of GP seem to correspond.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lorenz, Florian UNSPECIFIED orcid.org/0000-0002-8535-5243 UNSPECIFIED Brunner, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Berlth, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Dratsch, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Babic, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Hans Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Celik, Erkan UNSPECIFIED orcid.org/0000-0001-5687-7707 UNSPECIFIED dos Santos, Daniel Pinto UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimminger, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane Josephine UNSPECIFIED UNSPECIFIED UNSPECIFIED Goeser, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Chon, Seung-Hun UNSPECIFIED orcid.org/0000-0002-8923-6428 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-676237
DOI:	10.1007/s11605-022-05502-x
Journal or Publication Title:	J. Gastrointest. Surg.
Volume:	27
Number:	4
Page Range:	S. 682 - 691
Date:	2023
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1873-4626
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEVERITY Multiple languages Gastroenterology & Hepatology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67623