Universität zu Köln

Zhou, Kai, Hennes, Marc, Maier, Berenike ORCID: 0000-0001-6971-9927, Gompper, Gerhard ORCID: 0000-0002-8904-0986 and Sabass, Benedikt (2022). Non-equilibrium dynamics of bacterial colonies-growth, active fluctuations, segregation, adhesion, and invasion. Commun. Phys., 5 (1). BERLIN: NATURE PORTFOLIO. ISSN 2399-3650

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Abstract

Adhesion forces due to active pili govern the formation of biofilms by a wide range of bacteria. Using simulations, this work shows how such active adhesions determine the morphology of bacterial collectives, their non-equilibrium fluctuations, and the spreading dynamics in different geometries. Colonies of bacteria endowed with a pili-based self-propulsion machinery are ideal models for investigating the structure and dynamics of active many-particle systems. We study Neisseria gonorrhoeae colonies with a molecular-dynamics-based approach. A generic, adaptable simulation method for particle systems with fluctuating bond-like interactions is devised. The simulations are employed to investigate growth of bacterial colonies and the dependence of the colony structure on cell-cell interactions. In colonies, pilus retraction enhances local ordering. For colonies consisting of different types of cells, the simulations show a segregation depending on the pili-mediated interactions among different cells. These results agree with experimental observations. Next, we quantify the power-spectral density of colony-shape fluctuations in silico. Simulations predict a strong violation of the equilibrium fluctuation-response relation. Furthermore, we show that active force generation enables colonies to spread on surfaces and to invade narrow channels. The methodology can serve as a foundation for future studies of active many-particle systems at boundaries with complex shape.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhou, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennes, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Berenike UNSPECIFIED orcid.org/0000-0001-6971-9927 UNSPECIFIED Gompper, Gerhard UNSPECIFIED orcid.org/0000-0002-8904-0986 UNSPECIFIED Sabass, Benedikt UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-676664
DOI:	10.1038/s42005-022-01018-7
Journal or Publication Title:	Commun. Phys.
Volume:	5
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2399-3650
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-DIVISION; RETRACTION; ATTACHMENT; EXTENSION Multiple languages Physics, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67666