ToVinh, Michael, Hoerr, Gregor, Hoffmeister, Christoph, Dobrikova, Kristiyana, Gotter, Christina, Raabe, Jan, Kaiser, Kim M., Ahmad, Sarah, Finnemann, Claudia, Matejec, Eyleen, Hack, Gudrun, Bischoff, Jenny ORCID: 0000-0002-7700-2915, Rieke, Gereon J., Schwarze-Zander, Carolynne, Boesecke, Christoph, van Bremen, Kathrin, Wasmuth, Jan-Christian, Eis-Huebinger, Anna M., Streeck, Hendrik, Verhasselt, Hedda L., Oldenburg, Johannes, Strassburg, Christian P., Rockstroh, Juergen K., Spengler, Ulrich, Kraemer, Benjamin and Nattermann, Jacob . HIV-Associated Microbial Translocation May Affect Cytokine Production of CD56(bright) NK Cells via Stimulation of Monocytes. J. Infect. Dis.. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6613

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Abstract

The mechanisms involved in HIV-associated natural killer (NK) cell impairment are still incompletely understood. We observed HIV infection to be associated with increased plasma levels of IFABP, a marker for gut epithelial barrier dysfunction, and LBP, a marker for microbial translocation. Both IFABP and LBP plasma concentrations were inversely correlated with NK cell interferon-gamma production, suggesting microbial translocation to modulate NK cell functions. Accordingly, we found lipopolysaccharide to have an indirect inhibitory effect on NK cells via triggering monocytes' transforming growth factor-beta production. Taken together, our data suggest increased microbial translocation to be involved in HIV-associated NK cell dysfunction.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
ToVinh, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoerr, GregorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmeister, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobrikova, KristiyanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gotter, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raabe, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, Kim M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahmad, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finnemann, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matejec, EyleenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hack, GudrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bischoff, JennyUNSPECIFIEDorcid.org/0000-0002-7700-2915UNSPECIFIED
Rieke, Gereon J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarze-Zander, CarolynneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boesecke, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Bremen, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wasmuth, Jan-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eis-Huebinger, Anna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Streeck, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verhasselt, Hedda L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oldenburg, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strassburg, Christian P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rockstroh, Juergen K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spengler, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraemer, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nattermann, JacobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-677701
DOI: 10.1093/infdis/jiac485
Journal or Publication Title: J. Infect. Dis.
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1537-6613
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DISEASE PROGRESSION; PROLIFERATION; GROWTHMultiple languages
Immunology; Infectious Diseases; MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/67770

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