Universität zu Köln

Li, Jing, Ruegamer, Tamara, Brochhausen, Christoph ORCID: 0000-0002-6761-0247, Menhart, Karin ORCID: 0000-0002-4529-7819, Hiergeist, Andreas ORCID: 0000-0002-3154-0638, Kraemer, Lukas, Hellwig, Dirk ORCID: 0000-0002-3056-0143, Maier, Lars S., Schmid, Christof, Jantsch, Jonathan and Schach, Christian ORCID: 0000-0001-9560-4015 (2022). Infective Endocarditis: Predictive Factors for Diagnosis and Mortality in Surgically Treated Patients. J. Cardiovasc. Dev. Dis., 9 (12). BASEL: MDPI. ISSN 2308-3425

Full text not available from this repository.

Abstract

Background: Diagnosis of infective endocarditis (IE) often is challenging, and mortality is high in such patients. Our goal was to characterize common diagnostic tools to enable a rapid and accurate diagnosis and to correlate these tools with mortality outcomes. Methods: Because of the possibility of including perioperative diagnostics, only surgically treated patients with suspected left-sided IE were included in this retrospective, monocentric study. A clinical committee confirmed the diagnosis of IE. Results: 201 consecutive patients (age 64 +/- 13 years, 74% male) were finally diagnosed with IE, and 14 patients turned out IE-negative. Preoperative tests with the highest sensitivity for IE were positive blood cultures (89.0%) and transesophageal echocardiography (87.5%). In receiver operating characteristics, vegetation size revealed high predictive power for IE (AUC 0.800, p < 0.001) with an optimal cut-off value of 11.5 mm. Systemic embolism was associated with mortality, and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) had predictive power for mortality. Conclusion: If diagnostic standard tools remain inconclusive, we suggest employing novel cut-off values to increase diagnostic accuracy and accelerate diagnosis. Patients with embolism or elevated NT-proBNP deserve a closer follow-up.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Li, Jing UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruegamer, Tamara UNSPECIFIED UNSPECIFIED UNSPECIFIED Brochhausen, Christoph UNSPECIFIED orcid.org/0000-0002-6761-0247 UNSPECIFIED Menhart, Karin UNSPECIFIED orcid.org/0000-0002-4529-7819 UNSPECIFIED Hiergeist, Andreas UNSPECIFIED orcid.org/0000-0002-3154-0638 UNSPECIFIED Kraemer, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellwig, Dirk UNSPECIFIED orcid.org/0000-0002-3056-0143 UNSPECIFIED Maier, Lars S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Jantsch, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Schach, Christian UNSPECIFIED orcid.org/0000-0001-9560-4015 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-677710
DOI:	10.3390/jcdd9120467
Journal or Publication Title:	J. Cardiovasc. Dev. Dis.
Volume:	9
Number:	12
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2308-3425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIAC-SURGERY; RISK; CRITERIA; COMPLICATIONS; ASSOCIATION; MANAGEMENT; ADULTS; VALVES; IMPACT Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67771