Universität zu Köln

Ossendorff, R., Walter, S. G., Schildberg, F. A., Khoury, M. and Salzmann, G. M. (2022). CONTROVERSIES IN REGENERATIVE MEDICINE: SHOULD KNEE JOINT OSTEOARTHRITIS BE TREATED WITH MESENCHYMAL STROMAL CELLS? Eur. Cells Mater., 43. S. 98 - 112. DAVOS: AO RESEARCH INSTITUTE DAVOS-ARI. ISSN 1473-2262

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Abstract

Knee joint osteoarthritis is a complex immunological and degenerative disease. Current treatment strategies fail to alter its progression. Mesenchymal stromal cell (MSC) therapy for osteoarthritis has been object of research for more than 30 years. The aim of MSC therapy is intended to be holistic, with regeneration of all affected knee joint structures. The paracrine effect of the MSC secretome has been shown to be central for the regenerative capacity of MSCs. Activation of local knee-joint-specific MSCs leads to an immunomodulatory, anti-catabolic, anti-apoptotic and chondrogenic stimulus. Preclinical models have demonstrated the symptom-and disease-modifying effects of MSC therapy. At the bedside, there is evidence that autologous and allogeneic MSC therapy shows significant improvement in symptom-modifying and functional outcome. Despite this, a variety of contradictory clinical outcomes are available in the literature. The effectiveness of MSC therapy is still unclear, although there have been promising results. Regarding the diversity of cell sources, isolation, culture protocols and other factors, a comparison of different studies is difficult. Clinical translation of disease-modifying effects has not yet been shown. This narrative review presents a controversial overview of the current preclinical and clinical studies on MSC therapy in knee joint osteoarthritis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ossendorff, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, S. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildberg, F. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Khoury, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Salzmann, G. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-678114
DOI:	10.22203/eCM.v043a09
Journal or Publication Title:	Eur. Cells Mater.
Volume:	43
Page Range:	S. 98 - 112
Date:	2022
Publisher:	AO RESEARCH INSTITUTE DAVOS-ARI
Place of Publication:	DAVOS
ISSN:	1473-2262
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELLS; INTRAARTICULAR INJECTION; ARTICULAR-CARTILAGE; THERAPY; CULTURE; DEFECTS; ACTIVATION; LESIONS Multiple languages Cell & Tissue Engineering; Engineering, Biomedical; Materials Science, Biomaterials; Orthopedics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67811