Universität zu Köln

Fare, Anthea de Sainte, Bedei, Ivonne, Wolter, Aline, Schenk, Johanna, Widriani, Ellydda, Keil, Corinna ORCID: 0000-0002-1455-1319, Koehler, Siegmund, Bahlmann, Franz, Strizek, Brigitte ORCID: 0000-0003-3625-7097, Gembruch, Ulrich ORCID: 0000-0001-8284-4669, Berg, Christoph and Axt-Fliedner, Roland (2022). The Value of Delta Middle Cerebral Artery Peak Systolic Velocity for the Prediction of Twin Anemia-Polycythemia Sequence-Analysis of a Heterogenous Cohort of Monochorionic Twins. J. Clin. Med., 11 (24). BASEL: MDPI. ISSN 2077-0383

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Abstract

Introduction: Twin anemia-polycythemia sequence (TAPS) is a complication in monochorionic-diamniotic (MCDA) twin pregnancies. This study analyzes whether the prenatal diagnosis using delta middle cerebral artery-peak systolic velocity (MCA-PSV) > 0.5 multiples of the median (MoM) (delta group) detects more TAPS cases than the guideline-based diagnosis using the MCA-PSV cut off levels of >1.5 and <1.0 MoM (cut-off group), in a heterogenous group of MCDA twins. Methods: A retrospective analysis of 348 live-born MCDA twin pregnancies from 2010 to 2021 with available information on MCA-PSV within one week before delivery and hemoglobin-values within 24 h postnatally were considered eligible. Results: Among postnatal confirmed twin pairs with TAPS, the cut-off group showed lower sensitivity than the delta group (33% vs. 82%). Specificity proved higher in the cut-off group with 97% than in the delta group at 86%. The risk that a TAPS is mistakenly not recognized prenatally is higher in the cut-off group than in the delta group (52% vs. 18%). Conclusions: Our data shows that delta MCA-PSV > 0.5 MoM detects more cases of TAPS, which would not have been diagnosed prenatally according to the current guidelines. In the collective examined in the present study, TAPS diagnostics using delta MCA-PSV proved to be a more robust method.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fare, Anthea de Sainte UNSPECIFIED UNSPECIFIED UNSPECIFIED Bedei, Ivonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolter, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Schenk, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Widriani, Ellydda UNSPECIFIED UNSPECIFIED UNSPECIFIED Keil, Corinna UNSPECIFIED orcid.org/0000-0002-1455-1319 UNSPECIFIED Koehler, Siegmund UNSPECIFIED UNSPECIFIED UNSPECIFIED Bahlmann, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Strizek, Brigitte UNSPECIFIED orcid.org/0000-0003-3625-7097 UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Axt-Fliedner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-678126
DOI:	10.3390/jcm11247541
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	24
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIAGNOSTIC-CRITERIA; PERINATAL MANAGEMENT; COMPLICATIONS; PATHOGENESIS; PREGNANCY Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67812