Camargo, Carlos Henrique, Yamada, Amanda Yaeko, Nagamori, Filipe Onishi, de Souza, Andreia Rodrigues, Tiba-Casas, Monique Ribeiro, de Moraes Franca, Flavia Aparecida, Trigueiro Nobrega Porto, Maria Helena, de Lima Garzon, Magda Lourdes, Higgins, Paul ORCID: 0000-0001-8677-9454, Madalosso, Geraldine ORCID: 0000-0001-9501-6205 and de Assis, Denise Brandao (2022). Clonal spread of ArmA- and OXA-23-coproducing Acinetobacter baumannii International Clone 2 in Brazil during the first wave of the COVID-19 pandemic. J. Med. Microbiol., 71 (4). LONDON: MICROBIOLOGY SOC. ISSN 1473-5644

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Abstract

Introduction. Carbapenem-resistant Acinetobacter baumannii (CRAB) is the primary pathogen causing hospital-acquired infections. The spread of CRAB is mainly driven by the dissemination of resistant clones, and in Latin America, International Clones IC -1 (also known as clonal complex CC1), IC -4 (CC15) and IC -5 (CC79) are the most prevalent. Gap Statement. There are no documented outbreaks of CRAB International Clone 2 (IC -2) reported in Brazil. Aim. To describe a large outbreak of CRAB caused by the uncommon IC -2 in a Brazilian COVID- 19 hospital. Methodology. From May 2020 to May 2021, 224 patients infected or colonized with CRAB were identified in a single hospital; 92 % of them were also infected with SARS-CoV- 2. From these patients, 137 isolates were recovered and subjected to antimicrobial susceptibility testing, PCR analysis and molecular typing. Whole-genome sequencing and downstream analysis were carried out on a representative isolate (the first available isolate). Results. In 76 % of the patients, a single OXA- 23-producing CRAB IC -2 was identified. All the isolates were susceptible to polymyxin B, but highly resistant (>95 %) to aminoglycosides, fluoroquinolones and beta-lactams. Genomic analysis revealed that the representative isolate also carried the 16S rRNA Methylase ArmA, which was detected for the first time in this species in Brazil. Conclusion. We report the rapid spread of an emerging CRAB clone responsible for causing a large outbreak in a hospital in Brazil, a country with predominance of other CRAB clones. Continuous and prospective surveillance is warranted to evaluate the impact of this clone in Brazilian hospital settings.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Camargo, Carlos HenriqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yamada, Amanda YaekoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nagamori, Filipe OnishiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Souza, Andreia RodriguesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tiba-Casas, Monique RibeiroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Moraes Franca, Flavia AparecidaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trigueiro Nobrega Porto, Maria HelenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Lima Garzon, Magda LourdesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Higgins, PaulUNSPECIFIEDorcid.org/0000-0001-8677-9454UNSPECIFIED
Madalosso, GeraldineUNSPECIFIEDorcid.org/0000-0001-9501-6205UNSPECIFIED
de Assis, Denise BrandaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-678534
DOI: 10.1099/jmm.0.001509
Journal or Publication Title: J. Med. Microbiol.
Volume: 71
Number: 4
Date: 2022
Publisher: MICROBIOLOGY SOC
Place of Publication: LONDON
ISSN: 1473-5644
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PREVALENT OXA CARBAPENEMASES; MULTIPLEX-PCR; INFECTIONS; EMERGENCE; RESISTANCE; HOSPITALS; LINEAGESMultiple languages
MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/67853

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