Universität zu Köln

Baess, Susanne C., Burkhart, Ann-Kathrin ORCID: 0000-0003-4128-6677, Cappello, Sabrina, Graband, Annika ORCID: 0000-0002-9038-0734, Sere, Kristin, Zenke, Martin, Niemann, Catherin and Iden, Sandra (2022). Lrig1-and Wnt-dependent niches dictate segregation of resident immune cells and melanocytes in murine tail epidermis. Development, 149 (14). CAMBRIDGE: COMPANY BIOLOGISTS LTD. ISSN 1477-9129

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Abstract

The barrier-forming, self-renewing mammalian epidermis comprises keratinocytes, pigment-producing melanocytes and resident immune cells as first-line host defense. In murine tail skin, interfollicular epidermis patterns into pigmented 'scale' and hypopigmented 'interscale' epidermis. Why and how mature melanocytes accumulate in scale epidermis is unresolved. Here, we delineate a cellular hierarchy among epidermal cell types that determines skin patterning. Already during postnatal development, melanocytes co-segregate with newly forming scale compartments. Intriguingly, this process coincides with partitioning of both Langerhans cells and dendritic epidermal T cells to interscale epidermis, suggesting functional segregation of pigmentation and immune surveillance. Analysis of non-pigmented mice and of mice lacking melanocytes or resident immune cells revealed that immunocyte patterning is melanocyte and melanin independent and, vice versa, immune cells do not control melanocyte localization. Instead, genetically enforced progressive scale fusion upon Lrig1 deletion showed that melanocytes and immune cells dynamically follow epithelial scale:interscale patterns. Importantly, disrupting Wnt-Lef1 function in keratinocytes caused melanocyte mislocalization to interscale epidermis, implicating canonical Wnt signaling in organizing the pigmentation pattern. Together, this work uncovers cellular and molecular principles underlying the compartmentalization of tissue functions in skin.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baess, Susanne C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burkhart, Ann-Kathrin UNSPECIFIED orcid.org/0000-0003-4128-6677 UNSPECIFIED Cappello, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED Graband, Annika UNSPECIFIED orcid.org/0000-0002-9038-0734 UNSPECIFIED Sere, Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Zenke, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Niemann, Catherin UNSPECIFIED UNSPECIFIED UNSPECIFIED Iden, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-678569
DOI:	10.1242/dev.200154
Journal or Publication Title:	Development
Volume:	149
Number:	14
Date:	2022
Publisher:	COMPANY BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9129
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LANGERHANS CELLS; T-CELLS; STEM-CELLS; INTERFOLLICULAR EPIDERMIS; MOUSE EPIDERMIS; HAIR-FOLLICLES; STEADY-STATE; SKIN; MELANIN; EXPRESSION Multiple languages Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67856