Universität zu Köln

Ralevski, Alexandra, Apelt, Federico, Olas, Justyna J., Mueller-Roeber, Bernd, Rugarli, Elena I., Kragler, Friedrich and Horvath, Tamas L. (2022). Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice. Cell. Mol. Life Sci., 79 (6). BASEL: SPRINGER BASEL AG. ISSN 1420-9071

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Abstract

Mitochondria in animals are associated with development, as well as physiological and pathological behaviors. Several conserved mitochondrial genes exist between plants and higher eukaryotes. Yet, the similarities in mitochondrial function between plant and animal species is poorly understood. Here, we show that FMT (FRIENDLY MITOCHONDRIA) from Arabidopsis thaliana, a highly conserved homolog of the mammalian CLUH (CLUSTERED MITOCHONDRIA) gene family encoding mitochondrial proteins associated with developmental alterations and adult physiological and pathological behaviors, affects whole plant morphology and development under both stressed and normal growth conditions. FMT was found to regulate mitochondrial morphology and dynamics, germination, and flowering time. It also affects leaf expansion growth, salt stress responses and hyponastic behavior, including changes in speed of hyponastic movements. Strikingly, Cluh(+/-) heterozygous knockout mice also displayed altered locomotive movements, traveling for shorter distances and had slower average and maximum speeds in the open field test. These observations indicate that homologous mitochondrial genes may play similar roles and affect homologous functions in both plants and animals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ralevski, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Apelt, Federico UNSPECIFIED UNSPECIFIED UNSPECIFIED Olas, Justyna J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller-Roeber, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Rugarli, Elena I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kragler, Friedrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Horvath, Tamas L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-678647
DOI:	10.1007/s00018-022-04382-3
Journal or Publication Title:	Cell. Mol. Life Sci.
Volume:	79
Number:	6
Date:	2022
Publisher:	SPRINGER BASEL AG
Place of Publication:	BASEL
ISSN:	1420-9071
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OXIDATIVE STRESS; SALT; DYSFUNCTION; PROTEINS; BIOGENESIS; THALIANA; DYNAMICS; CLUELESS; FISSION; BINDING Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67864