Universität zu Köln

Kuntz, Thomas, Siebdrath, Julian, Hofmann, Silke C., Baltaci, Mehmet, Schaller, Joerg, Hellmich, Martin, von Goltzheim, Luise Stach, Assaf, Chalid, Oellig, Frank, Michalowitz, Alena-Lioba, Helbig, Doris and Kreuter, Alexander (2022). Increase of atypical fibroxanthoma and pleomorphic dermal sarcoma: a retrospective analysis of four German skin cancer centers. J. Dtsch. Dermatol. Ges., 20 (12). S. 1581 - 1589. HOBOKEN: WILEY. ISSN 1610-0387

Full text not available from this repository.

Abstract

Background and objectivesIn recent years, considerable insight has been gained into the pathogenesis, diagnosis and treatment of cutaneous sarcomas, including atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Both entities have shown increasing incidence rates in the last decade. This study was initiated to evaluate how these new insights impact the number of diagnoses of AFX/PDS compared to other cutaneous sarcoma entities. Patients and methodsIn a retrospective study of four German skin cancer centers, all histopathological reports of cutaneous sarcomas (AFX, PDS, dermatofibrosarcoma protuberans, cutaneous leiomyosarcoma, angiosarcoma, and Kaposi sarcoma) confirmed by board-certified dermatopathologists were analyzed during a time-period of seven years (2013-2019). Additionally, utilization of immunohistochemical markers (including pan-cytokeratin, S100, desmin, CD34, CD10, procollagen-1, CD99, CD14, and CD68) as an adjunct to diagnose AFX/PDS was recorded. ResultsOverall, 255 cutaneous sarcomas were included in the present study. The diagnosis of a cutaneous sarcoma has consequently risen from 2013 to 2019 (from 16 to 52 annual cases). The results of AFX/PDS revealed 4.6 times more diagnoses in 2019 than in 2013. Atypical fibroxanthoma represented the most common subtype, displaying 49.3 % of all diagnosed cutaneous sarcomas. Additionally, the increase of AFX/PDS was linked to the use of immunohistochemistry, with specific immunohistochemical markers used in 57.1 % of cases in 2013 compared to 100 % in 2019. ConclusionsThis retrospective study of four German skin cancer centers demonstrates a substantial rise of AFX/PDS, possibly due to recently established diagnostic and terminology standards. This rise is probably linked to increased utilization of specific immunohistochemical markers. Atypical fibroxanthoma/PDS may be more common than previously thought and seems to represent the most frequent cutaneous sarcoma subtype.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuntz, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Siebdrath, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hofmann, Silke C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baltaci, Mehmet UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaller, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED von Goltzheim, Luise Stach UNSPECIFIED UNSPECIFIED UNSPECIFIED Assaf, Chalid UNSPECIFIED UNSPECIFIED UNSPECIFIED Oellig, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Michalowitz, Alena-Lioba UNSPECIFIED UNSPECIFIED UNSPECIFIED Helbig, Doris UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-678697
DOI:	10.1111/ddg.14911
Journal or Publication Title:	J. Dtsch. Dermatol. Ges.
Volume:	20
Number:	12
Page Range:	S. 1581 - 1589
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1610-0387
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DERMATOFIBROSARCOMA PROTUBERANS; DIAGNOSIS; EXPRESSION; CD10 Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67869