Universität zu Köln

Hensel, Lukas, Lange, Fabian, Tscherpel, Caroline, Viswanathan, Shivakumar ORCID: 0000-0002-7513-3778, Freytag, Jana, Volz, Lukas J., Eickhoff, Simon B., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Grefkes, Christian (2023). Recovered grasping performance after stroke depends on interhemispheric frontoparietal connectivity. Brain, 146 (3). S. 1006 - 1021. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2156

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Abstract

Activity changes in the ipsi- and contralesional parietal cortex and abnormal interhemispheric connectivity between these regions are commonly observed after stroke, however, their significance for motor recovery remains poorly understood. We here assessed the contribution of ipsilesional and contralesional anterior intraparietal cortex (aIPS) for hand motor function in 18 recovered chronic stroke patients and 18 healthy control subjects using a multimodal assessment consisting of resting-state functional MRI, motor task functional MRI, online-repetitive transcranial magnetic stimulation (rTMS) interference, and 3D movement kinematics. Effects were compared against two control stimulation sites, i.e. contralesional M1 and a sham stimulation condition. We found that patients with good motor outcome compared to patients with more substantial residual deficits featured increased resting-state connectivity between ipsilesional aIPS and contralesional aIPS as well as between ipsilesional aIPS and dorsal premotor cortex. Moreover, interhemispheric connectivity between ipsilesional M1 and contralesional M1 as well as ipsilesional aIPS and contralesional M1 correlated with better motor performance across tasks. TMS interference at individual aIPS and M1 coordinates led to differential effects depending on the motor task that was tested, i.e. index finger-tapping, rapid pointing movements, or a reach-grasp-lift task. Interfering with contralesional aIPS deteriorated the accuracy of grasping, especially in patients featuring higher connectivity between ipsi- and contralesional aIPS. In contrast, interference with the contralesional M1 led to impaired grasping speed in patients featuring higher connectivity between bilateral M1. These findings suggest differential roles of contralesional M1 and aIPS for distinct aspects of recovered hand motor function, depending on the reorganization of interhemispheric connectivity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hensel, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Tscherpel, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Viswanathan, Shivakumar UNSPECIFIED orcid.org/0000-0002-7513-3778 UNSPECIFIED Freytag, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Volz, Lukas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Grefkes, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-679131
DOI:	10.1093/brain/awac157
Journal or Publication Title:	Brain
Volume:	146
Number:	3
Page Range:	S. 1006 - 1021
Date:	2023
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2156
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; STATE FUNCTIONAL CONNECTIVITY; CONTRALESIONAL MOTOR CORTEX; ANTERIOR INTRAPARIETAL AREA; WHITE-MATTER CHANGES; PARIETAL CORTEX; PREMOTOR CORTEX; FMRI; REHABILITATION; REORGANIZATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67913