Universität zu Köln

Segref, Alexandra ORCID: 0000-0001-8095-4469, Vakkayil, Kavya L., Padvitski, Tsimafei ORCID: 0000-0001-9528-8657, Li, Qiaochu ORCID: 0000-0001-8032-9110, Kroef, Virginia, Lormann, Jakob, Koerner, Lioba, Finger, Fabian and Hoppe, Thorsten (2022). Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. Nat. Commun., 13 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

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Abstract

Organismal physiology and survival are influenced by environmental conditions and linked to protein quality control. Proteome integrity is achieved by maintaining an intricate balance between protein folding and degradation. In Caenorhabditis elegans, acute heat stress determines cell non-autonomous regulation of chaperone levels. However, how the perception of environmental changes, including physiological temperature, affects protein degradation remains largely unexplored. Here, we show that loss-of-function of dyf-1 in Caenorhabditis elegans associated with dysfunctional sensory neurons leads to defects in both temperature perception and thermal adaptation of the ubiquitin/proteasome system centered on thermosensory AFD neurons. Impaired perception of moderate temperature changes worsens ubiquitin-dependent proteolysis in intestinal cells. Brain-gut communication regulating protein turnover is mediated by upregulation of the insulin-like peptide INS-5 and inhibition of the calcineurin-regulated forkhead-box transcription factor DAF-16/FOXO. Our data indicate that perception of ambient temperature and its neuronal integration is important for the control of proteome integrity in complex organisms. .

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Segref, Alexandra UNSPECIFIED orcid.org/0000-0001-8095-4469 UNSPECIFIED Vakkayil, Kavya L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Padvitski, Tsimafei UNSPECIFIED orcid.org/0000-0001-9528-8657 UNSPECIFIED Li, Qiaochu UNSPECIFIED orcid.org/0000-0001-8032-9110 UNSPECIFIED Kroef, Virginia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lormann, Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Koerner, Lioba UNSPECIFIED UNSPECIFIED UNSPECIFIED Finger, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680057
DOI:	10.1038/s41467-022-33467-7
Journal or Publication Title:	Nat. Commun.
Volume:	13
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUROPEPTIDE GENE FAMILY; HEAT-SHOCK RESPONSE; C.-ELEGANS; EXPRESSION; IDENTIFICATION; NEURONS; HOMEOSTASIS; TRANSPORT; LONGEVITY; PATHWAYS Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68005