Universität zu Köln

Chellappa, Sarah L. ORCID: 0000-0002-6190-464X, Bromundt, Vivien, Frey, Sylvia, Schlote, Torsten, Goldblum, David ORCID: 0000-0002-2119-1710 and Cajochen, Christian ORCID: 0000-0003-2699-7171 (2022). Cross-sectional study of intraocular cataract lens replacement, circadian rest-activity rhythms, and sleep quality in older adults. Sleep, 45 (4). CARY: OXFORD UNIV PRESS INC. ISSN 1550-9109

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Abstract

Study Objectives Age-related cataract decreases light transmission at the most sensitive spectrum for circadian photoentrainment, with negative ramifications for human health. Here, we assessed whether intraocular lens replacement (IOL) in older patients with previous cataract was associated with increased stability and amplitude of circadian rest-activity rhythms, and improved sleep quality. Methods Our cross-sectional study included sixteen healthy older individuals without ocular diseases (controls; 55-80 years; 63.6 +/- 5.6y; 8 women) and 13 patients with previous cataract and bilateral IOL (eight with blue-blocking [BB] lens and five with ultraviolet-only [UV] blocking lens; 55-80 years; 69.9 +/- 5.2y; 9 women). The study comprised three weeks of at home rest-activity assessments using wrist-worn actigraphs, and each week preceded a laboratory protocol. Primary outcomes were actigraphy-derived interdaily stability, intradaily variability, and relative amplitude of circadian rest-activity rhythms. Secondary outcomes were actigraphy-assessed sleep quality (i.e. time in bed, sleep duration, sleep efficiency, mean wake bout time and fragmentation index). Results Patients with IOL had significantly higher interdaily stability (Group effect: pFDR =.001), but not intradaily variability (Group effect: pFDR = n.s.), and significantly higher relative amplitude of rest-activity rhythms (Group effect: pFDR < .001). Moreover, patients with IOL had significantly higher activity levels during the day and lower levels during the evening, as compared to healthy older controls (Group effect: pFDR = .03). Analyses of actigraphy-derived sleep parameters yielded no significant differences across groups (Group effect: all pFDR > .1). Conclusions Our cross-sectional study suggests that enhancing spectral lens transmission in patients with cataract may benefit their circadian health.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chellappa, Sarah L. UNSPECIFIED orcid.org/0000-0002-6190-464X UNSPECIFIED Bromundt, Vivien UNSPECIFIED UNSPECIFIED UNSPECIFIED Frey, Sylvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlote, Torsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldblum, David UNSPECIFIED orcid.org/0000-0002-2119-1710 UNSPECIFIED Cajochen, Christian UNSPECIFIED orcid.org/0000-0003-2699-7171 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680100
DOI:	10.1093/sleep/zsac027
Journal or Publication Title:	Sleep
Volume:	45
Number:	4
Date:	2022
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1550-9109
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AGE-RELATED-CHANGES; BLUE-LIGHT; SURGERY; BLOCKING; PHOTOENTRAINMENT; TRANSMISSION; SENSITIVITY; ULTRAVIOLET; KINETICS; YOUNG Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68010