Universität zu Köln

Moestl, Stefan, Hoffmann, Fabian, Hoenemann, Jan-Niklas, Alvero-Cruz, Jose Ramon, Rittweger, Jorn, Tank, Jens and Jordan, Jens ORCID: 0000-0003-4518-0706 (2022). Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods. eLife, 11. CAMBRIDGE: eLIFE SCIENCES PUBL LTD. ISSN 2050-084X

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Abstract

Background: Pulse wave velocity (PWV) independently predicts cardiovascular risk. Easy to use single-cuff oscillometric methods are utilized in clinical practice to estimate PWV. We applied the approach in master athletes to assess possible beneficial effects of lifelong exercise on vascular health. Furthermore, we compared single-cuff measurements with a two-cuff method in another cohort. Methods: We obtained single-cuff upper arm oscillometric measurements thrice in 129 master athletes aged 35-86 years and estimated PWV using the ArcSolver algorithm. We applied the same method in 24 healthy persons aged 24-55 years participating in a head down tilt bedrest study. In the latter group, we also obtained direct PWV measurements using a thigh cuff. Results: Estimated pulse velocity very highly correlated with age (R-2 = 0.90) in master athletes. Estimated PWV values were located on the same regression line like values obtained in participants of the head down tilt bed rest study. The modest correlation between estimated and measured PWV (R-2 0.40; p < 0.05) was attenuated after adjusting for age; the mean difference between PWV measurements was 1 m/s. Conclusions: Estimated PWV mainly reflects the entered age rather than true vascular properties and, therefore, failed detecting beneficial effects of lifelong exercise.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moestl, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenemann, Jan-Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Alvero-Cruz, Jose Ramon UNSPECIFIED UNSPECIFIED UNSPECIFIED Rittweger, Jorn UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED orcid.org/0000-0003-4518-0706 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680411
DOI:	10.7554/eLife.73428
Journal or Publication Title:	eLife
Volume:	11
Date:	2022
Publisher:	eLIFE SCIENCES PUBL LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68041