Universität zu Köln

Schaer, Selina, Muerner-Lavanchy, Ines, Schmidt, Stefanie J., Koenig, Julian ORCID: 0000-0003-1009-9625 and Kaess, Michael ORCID: 0000-0003-0031-7764 (2022). Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis. Front. Neuroendocrinol., 66. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-6808

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Abstract

Alterations in hypothalamic-pituitary-adrenal (HPA) axis and its effector hormone cortisol have been proposed as one possible mechanism linking child maltreatment experiences to health disparities. In this series of meta-analyses, we aimed to quantify the existing evidence on the effect of child maltreatment on various measures of HPA axis activity. The systematic literature search yielded 1,858 records, of which 87 studies (k = 132) were included. Using random-effects models, we found evidence for blunted cortisol stress reactivity in individuals exposed to child maltreatment. In contrast, no overall differences were found in any of the other HPA axis activity measures (including measures of daily activity, cortisol assessed in the context of pharmacological challenges and cumulative measures of cortisol secretion). The impact of several moderators (e.g., sex, psychopathology, study quality), the role of methodological shortcomings of existing studies, as well as potential directions for future research are discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schaer, Selina UNSPECIFIED UNSPECIFIED UNSPECIFIED Muerner-Lavanchy, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Stefanie J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Julian UNSPECIFIED orcid.org/0000-0003-1009-9625 UNSPECIFIED Kaess, Michael UNSPECIFIED orcid.org/0000-0003-0031-7764 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680510
DOI:	10.1016/j.yfrne.2022.100987
Journal or Publication Title:	Front. Neuroendocrinol.
Volume:	66
Date:	2022
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-6808
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORTISOL AWAKENING RESPONSE; EARLY-LIFE STRESS; CORTICOTROPIN-RELEASING HORMONE; HPA-AXIS; DIURNAL CORTISOL; SALIVARY CORTISOL; HAIR CORTISOL; SOCIAL STRESS; DEXAMETHASONE-SUPPRESSION; SEXUAL-ABUSE Multiple languages Endocrinology & Metabolism; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68051