Universität zu Köln

Sanchez-Arcos, Carlos, Paris, Debora ORCID: 0000-0003-4526-8353, Mazzella, Valerio ORCID: 0000-0001-8708-2392, Mutalipassi, Mirko ORCID: 0000-0002-5521-5303, Costantini, Maria, Buia, Maria Cristina, von Elert, Eric, Cutignano, Adele ORCID: 0000-0003-3035-9252 and Zupo, Valerio ORCID: 0000-0001-9766-8784 (2022). Responses of the Macroalga Ulva prolifera Muller to Ocean Acidification Revealed by Complementary NMR- and MS-Based Omics Approaches. Mar. Drugs, 20 (12). BASEL: MDPI. ISSN 1660-3397

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Abstract

Ocean acidification (OA) is a dramatic perturbation of seawater environments due to increasing anthropogenic emissions of CO2. Several studies indicated that OA frequently induces marine biota stress and a reduction of biodiversity. Here, we adopted the macroalga Ulva prolifera as a model and applied a complementary multi-omics approach to investigate the metabolic profiles under normal and acidified conditions. Our results show that U. prolifera grows at higher rates in acidified environments. Consistently, we observed lower sucrose and phosphocreatine concentrations in response to a higher demand of energy for growth and a higher availability of essential amino acids, likely related to increased protein biosynthesis. In addition, pathways leading to signaling and deterrent compounds appeared perturbed. Finally, a remarkable shift was observed here for the first time in the fatty acid composition of triglycerides, with a decrease in the relative abundance of PUFAs towards an appreciable increase of palmitic acid, thus suggesting a remodeling in lipid biosynthesis. Overall, our studies revealed modulation of several biosynthetic pathways under OA conditions in which, besides the possible effects on the marine ecosystem, the metabolic changes of the alga should be taken into account considering its potential nutraceutical applications.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sanchez-Arcos, Carlos UNSPECIFIED UNSPECIFIED UNSPECIFIED Paris, Debora UNSPECIFIED orcid.org/0000-0003-4526-8353 UNSPECIFIED Mazzella, Valerio UNSPECIFIED orcid.org/0000-0001-8708-2392 UNSPECIFIED Mutalipassi, Mirko UNSPECIFIED orcid.org/0000-0002-5521-5303 UNSPECIFIED Costantini, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Buia, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED von Elert, Eric UNSPECIFIED UNSPECIFIED UNSPECIFIED Cutignano, Adele UNSPECIFIED orcid.org/0000-0003-3035-9252 UNSPECIFIED Zupo, Valerio UNSPECIFIED orcid.org/0000-0001-9766-8784 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680520
DOI:	10.3390/md20120743
Journal or Publication Title:	Mar. Drugs
Volume:	20
Number:	12
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1660-3397
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLUTAMATE-DEHYDROGENASE; ENVIRONMENTAL METABOLOMICS; POSIDONIA-OCEANICA; SUCROSE METABOLISM; MARINE MACROALGAE; SPECTROMETRY DATA; CARBON-DIOXIDE; ELEVATED CO2; GROWTH; ALGAE Multiple languages Chemistry, Medicinal; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68052