Universität zu Köln

Chen, Jing, de la Roche, Luz Angela, Kahlert, Ulf D., Isachenko, Vladimir, Huang, Hui, Hennefruend, Joerg, Yan, Xiaohong, Chen, Qionghua, Shi, Wenjie and Li, Youzhu (2022). Artificial Ovary for Young Female Breast Cancer Patients. Front. Med., 9. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-858X

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Abstract

In recent decades, there has been increasing attention toward the quality of life of breast cancer (BC) survivors. Meeting the growing expectations of fertility preservation and the generation of biological offspring remains a great challenge for these patients. Conventional strategies for fertility preservation such as oocyte and embryo cryopreservation are not suitable for prepubertal cancer patients or in patients who need immediate cancer therapy. Ovarian tissue cryopreservation (OTC) before anticancer therapy and autotransplantation is an alternative option for these specific indications but has a risk of retransplantation malignant cells. An emerging strategy to resolve these issues is by constructing an artificial ovary combined with stem cells, which can support follicle proliferation and ensure sex hormone secretion. This promising technique can meet both demands of improving the quality of life and meanwhile fulfilling their expectation of biological offspring without the risk of cancer recurrence.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chen, Jing UNSPECIFIED UNSPECIFIED UNSPECIFIED de la Roche, Luz Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Kahlert, Ulf D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Isachenko, Vladimir UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Hui UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennefruend, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Yan, Xiaohong UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Qionghua UNSPECIFIED UNSPECIFIED UNSPECIFIED Shi, Wenjie UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Youzhu UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681256
DOI:	10.3389/fmed.2022.837022
Journal or Publication Title:	Front. Med.
Volume:	9
Date:	2022
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-858X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOLLICLE ISOLATION TECHNIQUE; FIBROBLAST-GROWTH-FACTOR; CELL-LIKE CELLS; FERTILITY PRESERVATION; PREANTRAL FOLLICLES; ANTRAL FOLLICLES; TISSUE; TRANSPLANTATION; SURVIVAL; CHEMOTHERAPY Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68125