Universität zu Köln

Ruethrich, Maria Madeleine, Giesen, Nicola, Mellinghoff, Sibylle C., Rieger, Christina T. and von Lilienfeld-Toal, Marie (2022). Cellular Immune Response after Vaccination in Patients with Cancer-Review on Past and Present Experiences. Vaccines, 10 (2). BASEL: MDPI. ISSN 2076-393X

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Abstract

Patients with cancer are at particular risk for infection but also have diminished vaccine responses, usually quantified by the level of specific antibodies. Nonetheless, vaccines are specifically recommended in this vulnerable patient group. Here, we discuss the cellular part of the vaccine response in patients with cancer. We summarize the experience with vaccines prior to and during the SARS-CoV-2 pandemic in different subgroups, and we discuss why, especially in patients with cancer, T cells may be the more reliable correlate of protection. Finally, we provide a brief outlook on options to improve the cellular response to vaccines.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ruethrich, Maria Madeleine UNSPECIFIED UNSPECIFIED UNSPECIFIED Giesen, Nicola UNSPECIFIED UNSPECIFIED UNSPECIFIED Mellinghoff, Sibylle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieger, Christina T. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Lilienfeld-Toal, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-682210
DOI:	10.3390/vaccines10020182
Journal or Publication Title:	Vaccines
Volume:	10
Number:	2
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-393X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CD4(+) T-CELLS; INFLUENZA VACCINATION; ANTIBODY-RESPONSES; ZOSTER VACCINE; B-CELL; HEMATOLOGIC MALIGNANCIES; TRANSPLANT RECIPIENTS; COVID-19 VACCINATION; INFECTIOUS-DISEASES; CYTOKINE PRODUCTION Multiple languages Immunology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68221