Universität zu Köln

Miroshnikova, Yekaterina A. and Wickstroem, Sara A. (2022). Mechanical Forces in Nuclear Organization. Cold Spring Harbor Perspect. Biol., 14 (1). COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. ISSN 1943-0264

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Abstract

Cells generate and sense mechanical forces that trigger biochemical signals to elicit cellular responses that control cell fate changes. Mechanical forces also physically distort neighboring cells and the surrounding connective tissue, which propagate mechanochemical signals over long distances to guide tissue patterning, organogenesis, and adult tissue homeostasis. As the largest and stiffest organelle, the nucleus is particularly sensitive to mechanical force and deformation. Nuclear responses to mechanical force include adaptations in chromatin architecture and transcriptional activity that trigger changes in cell state. These force-driven changes also influence the mechanical properties of chromatin and nuclei themselves to prevent aberrant alterations in nuclear shape and help maintain genome integrity. This review will discuss principles of nuclear mechanotransduction and chromatin mechanics and their role in DNA damage and cell fate regulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Miroshnikova, Yekaterina A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wickstroem, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-682374
DOI:	10.1101/cshperspect.a039685
Journal or Publication Title:	Cold Spring Harbor Perspect. Biol.
Volume:	14
Number:	1
Date:	2022
Publisher:	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Place of Publication:	COLD SPRING HARBOR
ISSN:	1943-0264
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DNA-DAMAGE; HISTONE ACETYLATION; CELL-MIGRATION; ENVELOPE; CHROMATIN; GENE; MECHANOTRANSDUCTION; CALCIUM; ACTIN; DEFORMATION Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68237