Universität zu Köln

von Spreckelsen, Niklas ORCID: 0000-0002-9873-1711, Kesseler, Christoph, Brokinkel, Benjamin, Goldbrunner, Roland, Perry, Arie and Mawrin, Christian (2022). Molecular neuropathology of brain-invasive meningiomas. Brain Pathol., 32 (2). HOBOKEN: WILEY. ISSN 1750-3639

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Abstract

Invasion of brain tissue by meningiomas has been identified as one key factor for meningioma recurrence. The identification of meningioma tumor tissue surrounded by brain tissue in neurosurgical samples has been touted as a criterion for atypical meningioma (CNS WHO grade 2), but is only rarely seen in the absence of other high-grade features, with brain-invasive otherwise benign (BIOB) meningiomas remaining controversial. While post-surgery irradiation therapy might be initiated in brain-invasive meningiomas to prevent recurrences, specific treatment approaches targeting key molecules involved in the invasive process are not established. Here we have compiled the current knowledge about mechanisms supporting brain tissue invasion by meningiomas and summarize preclinical models studying targeted therapies with potential inhibitory effects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Spreckelsen, Niklas UNSPECIFIED orcid.org/0000-0002-9873-1711 UNSPECIFIED Kesseler, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Brokinkel, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Perry, Arie UNSPECIFIED UNSPECIFIED UNSPECIFIED Mawrin, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683274
DOI:	10.1111/bpa.13048
Journal or Publication Title:	Brain Pathol.
Volume:	32
Number:	2
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1750-3639
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEALTH-ORGANIZATION GRADE; ENDOTHELIAL GROWTH-FACTOR; IMMUNOHISTOCHEMICAL EXPRESSION; CELL-ADHESION; MATRIX METALLOPROTEINASE-2; PLASMINOGEN-ACTIVATOR; ANAPLASTIC MENINGIOMA; TUMOR-GROWTH; CATHEPSIN-B; PROLIFERATION Multiple languages Clinical Neurology; Neurosciences; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68327