Universität zu Köln

Oudmaijer, Christiaan A. J., van den Boogaard, Winnie M. C., Komninos, Daphne S. J., Verwaaijen, Emma J., van Santen, Hanneke M., Lilien, Marc R., Hoeijmakers, Jan H. J., Wijnen, Marc H. W., van den Heuvel-Eibrink, Marry M. and Vermeij, Wilbert P. (2022). Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity. Front. Pediatr., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-2360

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Abstract

Childhood renal tumors account for around 6% of all childhood cancers and 90% of these cases are Wilms tumor. In Europe, the SIOP-RTSG approach is considered standard of care and has resulted in five-year survival rates of over 90%. Efforts to decrease toxicity are now being pursued. Short-term fasting (STF), a short but strong reduction in calorie-intake, is associated with improved fitness, enhanced coping with acute physical stress and a lower risk of age-associated diseases. STF temporarily reduces growth to boost resilience, maintenance, and defense-mechanisms, by which toxic side-effects of (oxidative) damage and inflammation are largely prevented. Renal surgery for Wilms tumor carries a risk of acute kidney injury (AKI) and pediatric patients that had an episode of AKI are at increased risk for developing chronic renal disease. STF could mitigate surgery-induced stress and could further improve outcomes. We aim to investigate the effect of STF on renal function recovery after renal tumor surgery by conducting a single-center, prospective, randomized, non-blinded, intervention study. Children diagnosed with a unilateral renal tumor and opting for curative treatment are eligible for inclusion. The main study objective is to investigate the potential decrease in occurrence of AKI due to STF. Secondary objectives include renal function recovery, child's wellbeing, physical functioning, and feasibility of and adherence to STF in children with cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oudmaijer, Christiaan A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Boogaard, Winnie M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Komninos, Daphne S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verwaaijen, Emma J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Santen, Hanneke M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lilien, Marc R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeijmakers, Jan H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wijnen, Marc H. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED van den Heuvel-Eibrink, Marry M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vermeij, Wilbert P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683289
DOI:	10.3389/fped.2022.828615
Journal or Publication Title:	Front. Pediatr.
Volume:	10
Date:	2022
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2296-2360
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NONMETASTATIC WILMS-TUMOR; TERM DIETARY RESTRICTION; QUALITY-OF-LIFE; THERAPY; KIDNEY; EPIDEMIOLOGY; SURVIVORS; INJURY; MANAGEMENT; RATIONALE Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68328