Universität zu Köln

Zhou, Jian-feng, Xiong, Yu, Kang, Xiaodong, Pan, Zhigang, Zhu, Qiangbin, Goldbrunner, Roland, Stavrinou, Lampis, Lin, Shu, Hu, Weipeng, Zheng, Feng and Stavrinou, Pantelis (2022). Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update. Stem Cell Res. Ther., 13 (1). LONDON: BMC. ISSN 1757-6512

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Abstract

Non-traumatic intracerebral hemorrhage is a highly destructive intracranial disease with high mortality and morbidity rates. The main risk factors for cerebral hemorrhage include hypertension, amyloidosis, vasculitis, drug abuse, coagulation dysfunction, and genetic factors. Clinically, surviving patients with intracerebral hemorrhage exhibit different degrees of neurological deficits after discharge. In recent years, with the development of regenerative medicine, an increasing number of researchers have begun to pay attention to stem cell and exosome therapy as a new method for the treatment of intracerebral hemorrhage, owing to their intrinsic potential in neuroprotection and neurorestoration. Many animal studies have shown that stem cells can directly or indirectly participate in the treatment of intracerebral hemorrhage through regeneration, differentiation, or secretion. However, considering the uncertainty of its safety and efficacy, clinical studies are still lacking. This article reviews the treatment of intracerebral hemorrhage using stem cells and exosomes from both preclinical and clinical studies and summarizes the possible mechanisms of stem cell therapy. This review aims to provide a reference for future research and new strategies for clinical treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhou, Jian-feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiong, Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED Kang, Xiaodong UNSPECIFIED UNSPECIFIED UNSPECIFIED Pan, Zhigang UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhu, Qiangbin UNSPECIFIED UNSPECIFIED UNSPECIFIED Goldbrunner, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Lampis UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Shu UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Weipeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Zheng, Feng UNSPECIFIED UNSPECIFIED UNSPECIFIED Stavrinou, Pantelis UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683296
DOI:	10.1186/s13287-022-02965-2
Journal or Publication Title:	Stem Cell Res. Ther.
Volume:	13
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1757-6512
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MARROW STROMAL CELLS; BLOOD-BRAIN-BARRIER; ENDOTHELIAL PROGENITOR CELLS; UMBILICAL-CORD BLOOD; INTERLEUKIN-1 RECEPTOR ANTAGONIST; PROMOTES FUNCTIONAL RECOVERY; BONE-MARROW; NEUROTROPHIC FACTOR; ISCHEMIC-STROKE; RAT MODEL Multiple languages Cell & Tissue Engineering; Cell Biology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68329