Universität zu Köln

Prasse, Tobias, Stratos, Ioannis, Niehoff, Anja ORCID: 0000-0002-4165-0929, Christ, Hildegard, Heck, Vincent, Meyer, Carolin and Mittlmeier, Thomas ORCID: 0000-0002-0536-8045 (2022). Bisphenol A-Related Effects on Bone Morphology and Biomechanical Properties in an Animal Model. Toxics, 10 (2). BASEL: MDPI. ISSN 2305-6304

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Abstract

Bisphenol A (BPA), which is contained in numerous plastic products, is known to act as an endocrine-disruptive, toxic, and carcinogenic chemical. This experimental series sought to determine the influence of BPA exposure on the femoral bone architecture and biomechanical properties of male and female Wistar rats. BPA was applied subcutaneously by using osmotic pumps. After 12 weeks, the bones were analyzed by micro-computed tomography (micro-CT) and a three-point bending test. Comparing the female low- and high-dose groups, a significantly greater marrow area (p = 0.047) was identified in the group exposed to a higher BPA concentration. In addition, the trabecular number tended to be higher in the female high-dose group when compared to the low-dose group (p > 0.05). The area moment of inertia also tended to be higher in the male high-dose group when compared to the male low-dose group (p > 0.05). Considering our results, BPA-related effects on the bone morphology in female Wistar rats are osteoanabolic after high-dose exposure, while, in male rats, a tendency toward negative effects on the bone morphology in terms of a reduced cross-sectional cortical area and total area could be demonstrated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prasse, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Stratos, Ioannis UNSPECIFIED UNSPECIFIED UNSPECIFIED Niehoff, Anja UNSPECIFIED orcid.org/0000-0002-4165-0929 UNSPECIFIED Christ, Hildegard UNSPECIFIED UNSPECIFIED UNSPECIFIED Heck, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Mittlmeier, Thomas UNSPECIFIED orcid.org/0000-0002-0536-8045 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683318
DOI:	10.3390/toxics10020086
Journal or Publication Title:	Toxics
Volume:	10
Number:	2
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2305-6304
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOSE DEVELOPMENTAL EXPOSURE; IN-VIVO; DIETARY; CANCER; BPA; RISK; RATS Multiple languages Environmental Sciences; Toxicology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68331