Universität zu Köln

Xie, Kun, Perna, Laura, Schoettker, Ben, Kliegel, Matthias ORCID: 0000-0002-2001-2522, Brenner, Hermann ORCID: 0000-0002-6129-1572 and Mons, Ute ORCID: 0000-0003-1764-6783 (2022). Type 2 diabetes mellitus and cognitive decline in older adults in Germany - results from a population-based cohort. BMC Geriatr., 22 (1). LONDON: BMC. ISSN 1471-2318

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Abstract

Background A large body of evidence supports a link between type 2 diabetes mellitus (T2DM) and cognitive function, including dementia. However, longitudinal studies on the association between T2DM and decline of cognitive function are scarce and reported mixed results, and we hence set out to investigate the cross-sectional and longitudinal association between T2DM and global as well as domain-specific cognitive performance. Methods We used multivariable regression models to assess associations of T2DM with cognitive performance and cognitive decline in a subsample of a population-based prospective cohort study (ESTHER). This subsample (n = 732) was aged 70 years and older and had participated in telephone-based cognitive function assessment (COGTEL) measuring global and domain-specific cognitive performance during the 5- and 8-year follow-up. Results Total COGTEL scores of patients with prevalent T2DM were 27.4 +/- 8.3 and 29.4 +/- 8.7 at the 5- and 8-year measurements, respectively, and were roughly two points lower than those of T2DM-free participants after adjustment for age and sex. In cross-sectional models, after adjustment for several potential confounders, performance in verbal short-term and long-term memory tasks was statistically significantly lower in participants with T2DM, but the association was attenuated after further adjustment for vascular risk factors. The difference in total COGTEL scores reflecting global cognitive function by T2DM status after full adjustment for confounders and vascular risk factors was equivalent to a decrement in global cognitive function associated with a four-year age difference. In longitudinal models, a statistically significantly stronger cognitive decline in patients with T2DM was observed for working memory. Conclusions In this sample of older individuals, T2DM was associated with worse performance and stronger decline in a cognitive function test. Memory-related domains were found to be particularly sensitive to T2DM. Further large-scale prospective studies are needed to clarify potential T2DM-related predictors of cognitive decline and possible consequences on the abilities to perform patient self-management tasks in diabetes care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Xie, Kun UNSPECIFIED UNSPECIFIED UNSPECIFIED Perna, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoettker, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Kliegel, Matthias UNSPECIFIED orcid.org/0000-0002-2001-2522 UNSPECIFIED Brenner, Hermann UNSPECIFIED orcid.org/0000-0002-6129-1572 UNSPECIFIED Mons, Ute UNSPECIFIED orcid.org/0000-0003-1764-6783 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683807
DOI:	10.1186/s12877-022-03151-y
Journal or Publication Title:	BMC Geriatr.
Volume:	22
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1471-2318
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SCREENING INSTRUMENT COGTEL; DYSFUNCTION; ASSOCIATION; MANAGEMENT Multiple languages Geriatrics & Gerontology; Gerontology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68380