Universität zu Köln

Bardakan, Michella M., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Zapparoli, Laura, Bottini, Gabriella, Paulesu, Eraldo and Weiss, Peter H. ORCID: 0000-0002-5230-9080 (2022). Imaging the neural underpinnings of freezing of gait in Parkinson's disease. NeuroImage-Clin., 35. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

Freezing of gait (FoG) is a paroxysmal and sporadic gait impairment that severely affects PD patients' quality of life. This review summarizes current neuroimaging investigations that characterize the neural underpinnings of FoG in PD. The review presents and discusses the latest advances across multiple methodological domains that shed light on structural correlates, connectivity changes, and activation patterns associated with the different pathophysiological models of FoG in PD. Resting-state fMRI studies mainly report cortico-striatal decoupling and disruptions in connectivity along the dorsal stream of visuomotor processing, thus supporting the 'interference' and the 'perceptual dysfunction' models of FoG. Task-based MRI studies employing virtual reality and motor imagery paradigms reveal a disruption in functional connectivity between cortical and subcortical regions and an increased recruitment of parieto-occipital regions, thus corroborating the 'interference' and 'perceptual dysfunction' models of FoG. The main findings of fNIRS studies of actual gait primarily reveal increased recruitment of frontal areas during gait, supporting the 'executive dysfunction' model of FoG. Finally, we discuss how identifying the neural substrates of FoG may open new avenues to develop efficient treatment strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bardakan, Michella M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Zapparoli, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Bottini, Gabriella UNSPECIFIED UNSPECIFIED UNSPECIFIED Paulesu, Eraldo UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-684161
DOI:	10.1016/j.nicl.2022.103123
Journal or Publication Title:	NeuroImage-Clin.
Volume:	35
Date:	2022
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	2213-1582
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL CONNECTIVITY; VIRTUAL-REALITY; MOTOR CORTEX; BRAIN; ACTIVATION; MOVEMENTS; WALKING; DISTURBANCES; STIMULATION; VARIABILITY Multiple languages Neuroimaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68416