Universität zu Köln

Passali, Desiderio, Barat, Veronica, Cadevall, Olga, Freire, Hugo Miguel, Grattagliano, Ignazio, Gutu, Ioan, Mosges, Ralph and Pavlysh, Andrey (2022). International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat. BMC Prim. Care, 23 (1). LONDON: BMC. ISSN 2731-4553

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Abstract

Background Benzydamine hydrochloride is a locally-acting Non-Steroidal Anti-Inflammatory Drug (NSAID) with combined local anesthetic and analgesic properties, indicated for the symptomatic relief of pain in acute sore throat. The aim of this study was to obtain an European Consensus among pharmacists, general practitioners and pediatricians on the appropriate use of benzydamine hydrochloride in the treatment of sore throat. Methods The authors developed a Delphi questionnaire organized into 15 statements focused on 4 topics: the mechanism of action of benzydamine, the benzydamine treatment in an adult patient and in a pediatric patient, and the advantages of benzydamine over other topical treatments. The survey was administered to a panel of to 320 participants including general practitioners, pediatricians, and pharmacists from 6 European countries (Italy, Germany, Portugal, Romania, Russia, and Spain), who rated their level of agreement or disagreement with each statement on a 6-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing/disagreeing with each statement. Results Panelists' agreement on statements was very high. Consensus was reached for all 15 statements in the Delphi survey, with more than 98% positive agreement on topic 4, suggesting a shared view among European healthcare professionals (HCPs) about the advantages of benzydamine over other topical treatments. A strong consensus (> 99%) was reached for all the statements of topic 1 regarding the mechanism of action of benzydamine, except for its anesthetic properties (79%). Strong agreement was reached for all statements in topics 2 and 3 regarding the treatment of acute sore throat symptoms in the adult and pediatric patient, except for one on the efficacy of benzydamine in preventing post-operative sore throat, for which it was 67%. Conclusion Because all relevant publications on benzydamine are dated and there are no recommendations on its use for the symptomatic treatment of sore throat in European guidelines, this Delphi-based international consensus may be important in reinforcing the appropriate use and effect of benzydamine in the treatment of sore throat among health care professionals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Passali, Desiderio UNSPECIFIED UNSPECIFIED UNSPECIFIED Barat, Veronica UNSPECIFIED UNSPECIFIED UNSPECIFIED Cadevall, Olga UNSPECIFIED UNSPECIFIED UNSPECIFIED Freire, Hugo Miguel UNSPECIFIED UNSPECIFIED UNSPECIFIED Grattagliano, Ignazio UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutu, Ioan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mosges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED Pavlysh, Andrey UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-684304
DOI:	10.1186/s12875-022-01901-w
Journal or Publication Title:	BMC Prim. Care
Volume:	23
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	2731-4553
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYTOKINE PRODUCTION; ORAL MUCOSITIS; DOUBLE-BLIND; EFFICACY; ANTIBIOTICS; ACETAMINOPHEN; INHIBITION; IBUPROFEN; CHILDREN; SAFETY Multiple languages Primary Health Care; Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68430