Li, Xianhe, Straub, Julian ORCID: 0000-0003-4544-6332, Medeiros, Tania Catarina, Mehra, Chahat ORCID: 0000-0003-3338-1527, den Brave, Fabian ORCID: 0000-0001-6955-4616, Peker, Esra, Atanassov, Ilian ORCID: 0000-0001-8259-2545, Stillger, Katharina ORCID: 0000-0001-5811-6389, Michaelis, Jonas Benjamin ORCID: 0000-0001-9548-2337, Burbridge, Emma, Adrain, Colin, Munch, Christian, Riemer, Jan ORCID: 0000-0002-7574-8457, Becker, Thomas and Pernas, Lena F. (2022). Mitochondria shed their outer membrane in response to infection-induced stress. Science, 375 (6577). S. 159 - 204. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

The outer mitochondrial membrane (OMM) is essential for cellular homeostasis. Yet little is known of the mechanisms that remodel it during natural stresses. We found that large SPOTs (structures positive for OMM) emerge during Toxoplasma gondii infection in mammalian cells. SPOTs mediated the depletion of the OMM proteins mitofusin 1 and 2, which restrict parasite growth. The formation of SPOTs depended on the parasite effector TgMAF1 and the host mitochondrial import receptor TOM70, which is required for optimal parasite proliferation. TOM70 enabled TgMAF1 to interact with the host OMM translocase SAM50. The ablation of SAM50 or the overexpression of an OMM-targeted protein promoted OMM remodeling independently of infection. Thus, Toxoplasma hijacks the formation of SPOTs, a cellular response to OMM stress, to promote its growth.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Li, XianheUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Straub, JulianUNSPECIFIEDorcid.org/0000-0003-4544-6332UNSPECIFIED
Medeiros, Tania CatarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehra, ChahatUNSPECIFIEDorcid.org/0000-0003-3338-1527UNSPECIFIED
den Brave, FabianUNSPECIFIEDorcid.org/0000-0001-6955-4616UNSPECIFIED
Peker, EsraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Atanassov, IlianUNSPECIFIEDorcid.org/0000-0001-8259-2545UNSPECIFIED
Stillger, KatharinaUNSPECIFIEDorcid.org/0000-0001-5811-6389UNSPECIFIED
Michaelis, Jonas BenjaminUNSPECIFIEDorcid.org/0000-0001-9548-2337UNSPECIFIED
Burbridge, EmmaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adrain, ColinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munch, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemer, JanUNSPECIFIEDorcid.org/0000-0002-7574-8457UNSPECIFIED
Becker, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pernas, Lena F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-685073
DOI: 10.1126/science.abi4343
Journal or Publication Title: Science
Volume: 375
Number: 6577
Page Range: S. 159 - 204
Date: 2022
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication: WASHINGTON
ISSN: 1095-9203
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TOXOPLASMA-GONDII; PROTEIN IMPORT; TRANSPORT; PARKIN; TRANSLOCATION; COMPARTMENTS; BIOGENESIS; CONTACT; FISSION; PATHWAYMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68507

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