Universität zu Köln

Goertz, Lukas, Weiss, Daniel, Abdullayev, Nuran ORCID: 0000-0003-4522-537X, Moenninghoff, Christoph, Borggrefe, Jan, Phung, Timo Huan, Haage, Patrick, Schlamann, Marc, Dorn, Franziska, Kaschner, Marius, Kabbasch, Christoph and Nordmeyer, Hannes (2022). Safety and Efficacy of the Novel Low-Profile APERIO Hybrid17 for a Treatment of Proximal and Distal Vessel Occlusion in Acute Ischemic Stroke: A Multi-Center Experience. World Neurosurg., 167. S. E386 - 11. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-8769

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Abstract

OBJECTIVE: To report our initial experience with the novel low-profile APERIO Hybrid17 Thrombectomy Device (AP17) for proximal and distal vessel occlusions in acute ischemic stroke.METHODS: A multicentric retrospective analysis of pa-tients treated with the AP17 was performed. The primary effectiveness endpoint was first-pass TICI >= 2b (Thrombol-ysis in cerebral infarction scale). The primary safety endpoint was the occurrence of hemorrhagic complications. Further outcome measures were number of passes, device -related complications, and 3-month functional outcome.RESULTS: The AP17 was used in 71 patients (mean age: 73 years) with a median baseline National Institutes of Health Stroke Scale score of 9. Treated vessels were the carotid-T in 8 cases (11%), the M1-segment in 16 (23%), the M2-segment in 29 (41%), the anterior cerebral artery in 3 (4%), and basilar/posterior cerebral arteries in 15 (21%). The rates of first-pass and final TICI >= 2b were 75.6% and 92.7%, retrospectively, with a mean number of passes of 3 +/- 2. Final TICI >= 2b rates were comparable between large and medium vessel occlusions. Symptomatic intracranial hemorrhages were recorded in 2 cases (2.8%). At 3-month clinical follow-up, a modified Rankin scale score 2 pound was achieved in 69.0% (29/42). The all-cause mortality at discharge was 17.4%.CONCLUSIONS: The AP17 was associated with a reasonable safety and efficacy profile for both proximal and distal vessel occlusions. These results may contribute to establish mechanical thrombectomy for distal occlusions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goertz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Abdullayev, Nuran UNSPECIFIED orcid.org/0000-0003-4522-537X UNSPECIFIED Moenninghoff, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Borggrefe, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Phung, Timo Huan UNSPECIFIED UNSPECIFIED UNSPECIFIED Haage, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlamann, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Dorn, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaschner, Marius UNSPECIFIED UNSPECIFIED UNSPECIFIED Kabbasch, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Nordmeyer, Hannes UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685367
DOI:	10.1016/j.wneu.2022.08.023
Journal or Publication Title:	World Neurosurg.
Volume:	167
Page Range:	S. E386 - 11
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-8769
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STENT-RETRIEVER THROMBECTOMY; MECHANICAL THROMBECTOMY; DEVICE Multiple languages Clinical Neurology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68536