Universität zu Köln

Canu, Daniela, Ioannou, Chara, Mueller, Katarina, Martin, Berthold, Fleischhaker, Christian, Biscaldi, Monica, Beauducel, Andre, Smyrnis, Nikolaos, van Elst, Ludger Tebartz and Klein, Christoph (2022). Evidence towards a continuum of impairment across neurodevelopmental disorders from basic ocular-motor tasks. Sci Rep, 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

Findings of genetic overlap between Schizophrenia, Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) contributed to a renewed conceptualization of these disorders as laying on a continuum based on aetiological, pathophysiological and neurodevelopmental features. Given that cognitive impairments are core to their pathophysiology, we compared patients with schizophrenia, ADHD, ASD, and controls on ocular-motor and manual-motor tasks, challenging crucial cognitive processes. Group comparisons revealed inhibition deficits common to all disorders, increased intra-subject variability in schizophrenia and, to a lesser extent, ADHD as well as slowed processing in schizophrenia. Patterns of deviancies from controls exhibited strong correlations, along with differences that posited schizophrenia as the most impaired group, followed by ASD and ADHD. While vector correlations point towards a common neurodevelopmental continuum of impairment, vector levels suggest differences in the severity of such impairment. These findings argue towards a dimensional approach to Neurodevelopmental Disorders' pathophysiological mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Canu, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Ioannou, Chara UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Katarina UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Berthold UNSPECIFIED UNSPECIFIED UNSPECIFIED Fleischhaker, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Biscaldi, Monica UNSPECIFIED UNSPECIFIED UNSPECIFIED Beauducel, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Smyrnis, Nikolaos UNSPECIFIED UNSPECIFIED UNSPECIFIED van Elst, Ludger Tebartz UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685801
DOI:	10.1038/s41598-022-19661-z
Journal or Publication Title:	Sci Rep
Volume:	12
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; REACTION-TIME VARIABILITY; UNAFFECTED 1ST-DEGREE RELATIVES; RESPONSE-INHIBITION; WORKING-MEMORY; SCHIZOPHRENIA-PATIENTS; SACCADIC LATENCY; EYE-MOVEMENTS; RISK-FACTORS; ADHD Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68580