Universität zu Köln

Fingerhut, Stefanie, Buchholz, Rebecca, Buecker, Patrick, Clasen, Wolfgang, Sperling, Michael ORCID: 0000-0001-6676-2487, Mueller, Klaus-Michael, Rehkaemper, Jan, Radbruch, Alexander, Richter, Henning ORCID: 0000-0003-3696-6993, Jeibmann, Astrid and Karst, Uwe (2022). Gadolinium retention in the tunica media of arterial walls-a complementary study using elemental bioimaging and immunogold staining. Metallomics, 14 (6). OXFORD: OXFORD UNIV PRESS. ISSN 1756-591X

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Abstract

Gadolinium (Gd) deposition has been found in both animal and human tissues after injections of Gd-based contrast agents (GBCAs). Without the knowledge of which tissues are most affected, it is difficult to determine whether Gd accumulation could lead to any pathological changes. The current study aims at investigating histological sections of three patients who were exposed to GBCAs during their lifetime, and identify areas of Gd accumulation. Tissue sections of three autopsy cases were investigated by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) to assess the distribution of Gd, and the deposition within tissue sections was quantified. Additional application of laser ablation-inductively coupled plasma-optical emission spectroscopy (LA-ICP-OES) enabled a sensitive detection of calcium (Ca) in the vessel walls, which is usually impeded in LA-ICP-MS due to the isobaric interference with argon. Complementary LA-ICP-MS and LA-ICP-OES analysis revealed that Gd was co-localized with zinc and Ca, in the area where smooth muscle actin was present. Notably, high levels of Gd were found in the tunica media of arterial walls, which requires further research into potential Gd-related toxicity in this specific location.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fingerhut, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchholz, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED Buecker, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Clasen, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Sperling, Michael UNSPECIFIED orcid.org/0000-0001-6676-2487 UNSPECIFIED Mueller, Klaus-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehkaemper, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Radbruch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Henning UNSPECIFIED orcid.org/0000-0003-3696-6993 UNSPECIFIED Jeibmann, Astrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Karst, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685955
DOI:	10.1093/mtomcs/mfac029
Journal or Publication Title:	Metallomics
Volume:	14
Number:	6
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1756-591X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEPHROGENIC FIBROSING DERMOPATHY; HIGH-SIGNAL INTENSITY; UNENHANCED T1-WEIGHTED IMAGES; SYSTEMIC FIBROSIS; DENTATE NUCLEUS; CONTRAST AGENTS; GLOBUS-PALLIDUS; MULTIORGAN INVOLVEMENT; BRAIN; DEPOSITION Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68595