Royzman, Dmytro, Peckert-Maier, Katrin, Stich, Lena, Koenig, Christina ORCID: 0000-0002-6982-9701, Wild, Andreas B., Tauchi, Miyuki, Ostalecki, Christian, Kiesewetter, Franklin, Seyferth, Stefan, Lee, Geoffrey, Eming, Sabine A., Fuchs, Maximilian ORCID: 0000-0002-8099-9541, Kunz, Meik, Stuermer, Ewa K., Peters, Eva M. J., Berking, Carola, Zinser, Elisabeth and Steinkasserer, Alexander (2022). Soluble CD83 improves and accelerates wound healing by the induction of pro-resolving macrophages. Front. Immunol., 13. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-3224

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Abstract

To facilitate the recovery process of chronic and hard-to-heal wounds novel pro-resolving treatment options are urgently needed. We investigated the pro-regenerative properties of soluble CD83 (sCD83) on cutaneous wound healing, where sCD83 accelerated wound healing not only after systemic but also after topical application, which is of high therapeutic interest. Cytokine profile analyses revealed an initial upregulation of inflammatory mediators such as TNF alpha and IL-1 beta, followed by a switch towards pro-resolving factors, including YM-1 and IL-10, both expressed by tissue repair macrophages. These cells are known to mediate resolution of inflammation and stimulate wound healing processes by secretion of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), which promote vascularization as well as fibroblast and keratinocyte differentiation. In conclusion, we have found strong wound healing capacities of sCD83 beyond the previously described role in transplantation and autoimmunity. This makes sCD83 a promising candidate for the treatment of chronic- and hard-to-heal wounds.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Royzman, DmytroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peckert-Maier, KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stich, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, ChristinaUNSPECIFIEDorcid.org/0000-0002-6982-9701UNSPECIFIED
Wild, Andreas B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tauchi, MiyukiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ostalecki, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiesewetter, FranklinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seyferth, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, GeoffreyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eming, Sabine A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuchs, MaximilianUNSPECIFIEDorcid.org/0000-0002-8099-9541UNSPECIFIED
Kunz, MeikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stuermer, Ewa K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, Eva M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berking, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zinser, ElisabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinkasserer, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-686037
DOI: 10.3389/fimmu.2022.1012647
Journal or Publication Title: Front. Immunol.
Volume: 13
Date: 2022
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1664-3224
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LEUKOCYTE PROTEASE INHIBITOR; GROWTH-FACTORS; STEM-CELLS; ACTIVATION; DIFFERENTIATION; POLARIZATION; CYTOKINES; MURINE; MYOFIBROBLASTS; MODULATIONMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68603

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