Engelhard, Christoph Andreas, Huang, Chien ORCID: 0000-0001-8307-3544, Khani, Sajjad, Kasparek, Petr, Prochazka, Jan, Rozman, Jan, Reguera, David Pajuelo, Sedlacek, Radislav and Kornfeld, Jan-Wilhelm ORCID: 0000-0002-6802-4442 (2022). Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA Gm15551. Non-Coding RNA, 8 (3). BASEL: MDPI. ISSN 2311-553X

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Abstract

Cold and nutrient-activated brown adipose tissue (BAT) is capable of increasing systemic energy expenditure via the uncoupled respiration and secretion of endocrine factors, thereby protecting mice against diet-induced obesity and improving insulin response and glucose tolerance in men. Long non-coding RNAs (lncRNAs) have recently been identified as fine-tuning regulators of cellular function. While certain lncRNAs have been functionally characterised in adipose tissue, their overall contribution in the activation of BAT remains elusive. We identified lncRNAs correlating to interscapular brown adipose tissue (iBAT) function in a high fat diet (HFD) and cold stressed mice. We focused on Gm15551, which has an adipose tissue specific expression profile, is highly upregulated during adipogenesis, and downregulated by beta-adrenergic activation in mature adipocytes. Although we performed comprehensive transcriptional and adipocyte physiology profiling in vitro and in vivo, we could not detect an effect of gain or loss of function of Gm15551.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Engelhard, Christoph AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, ChienUNSPECIFIEDorcid.org/0000-0001-8307-3544UNSPECIFIED
Khani, SajjadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasparek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prochazka, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rozman, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reguera, David PajueloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sedlacek, RadislavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornfeld, Jan-WilhelmUNSPECIFIEDorcid.org/0000-0002-6802-4442UNSPECIFIED
URN: urn:nbn:de:hbz:38-686267
DOI: 10.3390/ncrna8030032
Journal or Publication Title: Non-Coding RNA
Volume: 8
Number: 3
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2311-553X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BODY-MASS INDEX; GENE-EXPRESSION; BROWN FAT; INTERLEUKIN-1-BETA; MORTALITY; OBESITY; MUSCLEMultiple languages
Biochemistry & Molecular Biology; Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68626

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