Universität zu Köln

Fend, Falko, Bonzheim, Irina, Kakkassery, Vinodh ORCID: 0000-0001-6212-8964, Heindl, Ludwig M. and Illerhaus, Gerald (2022). Lymphoma of the eye and its adnexa Modern pathological diagnostics and systemic treatment. Ophthalmologie, 119 (7). S. 664 - 675. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2731-7218

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Abstract

Background Malignant lymphomas of the eye and its adnexal structures account for approximately 5-15% of extranodal lymphomas. According to anatomic and biological criteria, two large groups of lymphomas in and around the eye need to be distinguished: (1) primary lymphomas of intraocular structures and (2) primary lymphomas of ocular adnexa. Furthermore, there is a large spectrum of secondary manifestations of malignant lymphomas in ocular and periocular structures. Objective This article gives a summary of the classification and molecular pathology of various intraocular and periocular lymphomas as well as oncological systemic treatment with a focus on primary vitreoretinal lymphomas. Methods A selective literature search was carried out in PubMed on the topic of intraocular and periocular lymphomas and own experiences are presented. Results The treatment of primary vitreoretinal lymphomas (PVRL) is an interdisciplinary challenge and despite the apparently localized disease, systemic treatment concepts are necessary to reduce the high risk of secondary involvement of the central nervous system (CNS). Therefore, it is crucial that the substances used can penetrate the CNS, and protocols should be chosen in accordance with the treatment concepts for primary CNS lymphomas. The knowledge on the genetics and biology of ocular lymphomas generated by modern high throughput methods enable not only improved diagnostics using molecular methods but also provide rationales for targeted therapeutic approaches. Conclusion A deep understanding of the biological and molecular principles of intraocular and periocular lymphomas forms a basic prerequisite for precise diagnostics and the use of targeted systemic treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fend, Falko UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonzheim, Irina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kakkassery, Vinodh UNSPECIFIED orcid.org/0000-0001-6212-8964 UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Illerhaus, Gerald UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-686978
DOI:	10.1007/s00347-022-01650-2
Journal or Publication Title:	Ophthalmologie
Volume:	119
Number:	7
Page Range:	S. 664 - 675
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2731-7218
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY INTRAOCULAR LYMPHOMA; PRIMARY CNS LYMPHOMA; B-CELL LYMPHOMA; PRIMARY VITREORETINAL LYMPHOMA; HIGH-DOSE METHOTREXATE; MALT LYMPHOMA; CHLAMYDIA-PSITTACI; HIGH-FREQUENCY; OCULAR ADNEXA; SINGLE-CENTER Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68697