Universität zu Köln

Gianelli, Umberto, Thiele, Juergen, Orazi, Attilio, Gangat, Naseema, Vannucchi, Alessandro M., Tefferi, Ayalew and Kvasnicka, Hans Michael (2023). International Consensus Classification of myeloid and lymphoid neoplasms: myeloproliferative neoplasms. Virchows Arch., 482 (1). S. 53 - 69. NEW YORK: SPRINGER. ISSN 1432-2307

Full text not available from this repository.

Abstract

The recently published International Consensus Classification (ICC) of myeloid neoplasms summarized the results of an in-depth effort by pathologists, oncologists, and geneticists aimed to update the 2017 World Health Organization classification system for hematopoietic tumors. Along these lines, several important modifications were implemented in the classification of myeloproliferative neoplasms (MPNs). For chronic myeloid leukemia, BCR::ABL1-positive, the definition of accelerated and blast phase was simplified, and in the BCR::ABL1-negative MPNs, the classification was slightly updated to improve diagnostic specificity with a more detailed and better validated morphologic approach and the recommendation of more sensitive molecular techniques to capture in particular early stage diseases. In this regard, high sensitive single target (RT-qPCR, ddPCR) or multi-target next-generation sequencing assays with a minimal sensitivity of VAF 1% are now important for a proper diagnostic identification of MPN cases with low allelic frequencies at initial presentation. This review discusses the updated diagnostic criteria of MPN according to the ICC, particularly by highlighting the new concepts and how they can be applied in clinical settings to obtain an appropriate prognostic relevant diagnosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gianelli, Umberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Orazi, Attilio UNSPECIFIED UNSPECIFIED UNSPECIFIED Gangat, Naseema UNSPECIFIED UNSPECIFIED UNSPECIFIED Vannucchi, Alessandro M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tefferi, Ayalew UNSPECIFIED UNSPECIFIED UNSPECIFIED Kvasnicka, Hans Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-687062
DOI:	10.1007/s00428-022-03480-8
Journal or Publication Title:	Virchows Arch.
Volume:	482
Number:	1
Page Range:	S. 53 - 69
Date:	2023
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-2307
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BONE-MARROW HISTOPATHOLOGY; CHRONIC NEUTROPHILIC LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; ESSENTIAL THROMBOCYTHEMIA; POLYCYTHEMIA-VERA; HYPEREOSINOPHILIC SYNDROME; VENOUS THROMBOSIS; DIAGNOSTIC IMPACT; ALLELE BURDEN; SURVIVAL Multiple languages Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68706