Universität zu Köln

Gruell, Henning, Vanshylla, Kanika ORCID: 0000-0003-4552-9170, Tober-Lau, Pinkus ORCID: 0000-0002-9148-3663, Hillus, David, Schommers, Philipp, Lehmann, Clara, Kurth, Florian ORCID: 0000-0002-3807-473X, Sander, Leif E. and Klein, Florian ORCID: 0000-0003-1376-1792 (2022). mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant. Nat. Med., 28 (3). S. 477 - 483. BERLIN: NATURE PORTFOLIO. ISSN 1546-170X

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Abstract

Neutralization of the SARS-CoV-2 Omicron variant is markedly impaired in sera from recipients of two doses of the COVID-19 vaccine BNT162b2 or from convalescent individuals, but is robustly increased in both groups following a booster vaccine dose. The Omicron variant of SARS-CoV-2 is causing a rapid increase in infections across the globe. This new variant of concern carries an unusually high number of mutations in key epitopes of neutralizing antibodies on the viral spike glycoprotein, suggesting potential immune evasion. Here we assessed serum neutralizing capacity in longitudinal cohorts of vaccinated and convalescent individuals, as well as monoclonal antibody activity against Omicron using pseudovirus neutralization assays. We report a near-complete lack of neutralizing activity against Omicron in polyclonal sera from individuals vaccinated with two doses of the BNT162b2 COVID-19 vaccine and from convalescent individuals, as well as resistance to different monoclonal antibodies in clinical use. However, mRNA booster immunizations in vaccinated and convalescent individuals resulted in a significant increase of serum neutralizing activity against Omicron. This study demonstrates that booster immunizations can critically improve the humoral immune response against the Omicron variant.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gruell, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Vanshylla, Kanika UNSPECIFIED orcid.org/0000-0003-4552-9170 UNSPECIFIED Tober-Lau, Pinkus UNSPECIFIED orcid.org/0000-0002-9148-3663 UNSPECIFIED Hillus, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Schommers, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Clara UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurth, Florian UNSPECIFIED orcid.org/0000-0002-3807-473X UNSPECIFIED Sander, Leif E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED orcid.org/0000-0003-1376-1792 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-687441
DOI:	10.1038/s41591-021-01676-0
Journal or Publication Title:	Nat. Med.
Volume:	28
Number:	3
Page Range:	S. 477 - 483
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	1546-170X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68744